Acute effects of Ganoderma lucidum on blood pressure in rats

Authors

  • PUNATE WEERATEERANGKUL Department of Physiology, Faculty of Medicine, Chiang Mai University
  • Rattapong Sungnoon Department of Physiology, Faculty of Medicine, Chiang Mai University

Keywords:

Linzhi, Ganoderma lucidum, hypertension, Acute effect

Abstract

Linzhi (Ganoderma lucidum) has been used as a medicinal herb continuously for a long time in the treatment of many conditions such as balancing the body, restoring the nervous system, treating diabetes, cancer and hypertension.  Previous studies found that the genetically hypertensive rats who received Lingzhi extract continuously for 4-7 weeks has been able to reduce high blood pressure.  The aim of the present study was to study the acute effects of Linzhi extract on normotensive condition and the NG-nitro-L-arginine methyl ester (L-NAME) induced hypertension.  The study was investigated in both normotensive and hypertensive conditions.  Each study, the animals were separated into three groups as control group and Linzhi treated groups (175 and 350 mg/kg, respectively).  In hypertensive condition, the animals were injected with L-NAME (10 mg/kg) intravenously to induce hypertension.  The hemodynamic parameters such as systolic, diastolic, mean arterial pressures and pulse rate were recorded to compare between experimental groups.  It was found that both concentrations of Linzhi extract did not change hemodynamic parameters of normotensive as well as hypertensive animals.  Linzhi extract (175 and 350 mg/kg) could not decrease blood pressure in the hypertensive condition induced by L-NAME.  Moreover, Linzhi extract did not alter hemodynamic parameters in normotensive animals.

References

Bishop KS, Kao CH, Xu Y, Glucina MP, Paterson RR, Ferguson LR. From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry 2015;114:56-65.

Boh B, Berovic M, Zhang J, Zhi-Bin L. Ganoderma lucidum and its pharmaceutically active compounds. Biotechnology Annual Review 2007;13:265-301.

Ahmed MF. Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement. Biomedicine & Pharmacotherapy 2018;107:507-519.

Chan SW, Tomlinson B, Chan P, Lam CWK. The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharmaceutical Biology 2021;59(1):1159-1169.

Morigiwa A, Kitabatake K, Fujimoto Y, Ikekawa N. Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. Chem Pharm Bull (Japan) 1986;34(7):3025-3028.

Hai-Bang T, Shimizu K. Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme. Phytochem Lett 2015;12:243-247.

Ansor NM, Abdullah N, Aminudin N. Anti-angiotensin converting enzyme (ACE) proteins from mycelia of Ganoderma lucidum (Curtis) P. Karst. BMC Complement Altern Med 2013:13:256.

Tran HB, Yamamoto A, Matsumoto S, Ito H, Igami K, Miyazaki T, et al. Hypotensive effects and angiotensin-converting enzyme inhibitory peptides of reishi (Ganoderma lingzhi) auto-digested extract. Molecules 2014;19(9):13473-13485.

Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, et al.Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database of Systematic Reviews 2015(2):Cd007259.

Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome. Scientific Reports 2016;6:29540.

Ma J, Ye Q, Hua Y, Zhang D, Cooper R, Chang MN, et al. New Lanostanoids from the Mushroom Ganoderma lucidum. Journal of Natural Products 2002;65(1):72-75.

Noguchi M, Kakuma T, Tomiyasu K, Yamada A, Itoh K, Konishi F, et al. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms. Asian Journal of Andrology 2008;10(5):777-785.

Kanmatsuse K, Kajiwara N, Hayashi K, Shimogaichi S, Fukinbara I, Ishikawa H, et al. Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105(10):942-947.

Tran HB, Yamamoto A, Matsumoto S, Ito H, Igami K, Miyazaki T, et al. Hypotensive effects and angiotensin-converting enzyme inhibitory peptides of reishi (Ganoderma lingzhi) auto-digested extract. Molecules 2014;19(9):13473-13485.

Kagaya Y, Hatakeyama S, Goto T, Miura N, Tsujimura N, Sakamoto K. Studies on Ganoderma lucidum-III the effects of Rokkaku Reishi extract on arterial pressure level and serum glucose level. Research Communications in Pharmacology and Toxicology 2001;6(1-2):135-138.

Kabir Y, Kimura S, Tamura T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). Journal of Nutritional Science and Vitaminology (Tokyo) 1988;34(4):433-438.

Shevelev OB, Seryapina AA, Zavjalov EL, Gerlinskaya LA, Goryachkovskaya TN, Slynko NM, et al. Hypotensive and neurometabolic effects of intragastric Reishi (Ganoderma lucidum) administration in hypertensive ISIAH rat strain. Phytomedicine 2018;41:1-6.

Xue H, Qiao J, Meng G, Wu F, Luo J, Chen H, et al. Effect of Ganoderma lucidum polysaccharides on hemodynamic and antioxidation in T2DM rats. Zhongguo Zhong Yao Za Zhi 2010;35(3):339-343.

Weerateerangkul P, Palee S, Chinda K, Chattipakorn SC, Chattipakorn N. Effects of Kaempferia parviflora Wall. Ex. Baker and sildenafil citrate on cGMP level, cardiac function, and intracellular Ca2+ regulation in rat hearts. Journal of Cardiovascular Pharmacology 2012;60(3):299-309.

Parasuraman S, Raveendran R. Measurement of invasive blood pressure in rats. Journal of Pharmacology and Pharmacotherapeutics 2012;3(2):172-177.

Weldon SM, Winquist RJ, Madwed JB. Differential effects of L-NAME on blood pressure and heart rate responses to acetylcholine and bradykinin in cynomolgus primates. J Pharmacol Exp Ther 1995;272(1):126-33.

แสดงผลของสารสกัดเห็ดหลินจือในสัตว์ทดลองที่มีภาวะความดันโลหิตสูง

Published

2023-12-23

How to Cite

1.
WEERATEERANGKUL P, Sungnoon R. Acute effects of Ganoderma lucidum on blood pressure in rats. Health Sci Tech Rev [Internet]. 2023 Dec. 23 [cited 2024 May 23];16(3):31-9. Available from: https://li01.tci-thaijo.org/index.php/journalup/article/view/258993