Acute effects of Ganoderma lucidum on blood pressure in rats
Keywords:
Linzhi, Ganoderma lucidum, hypertension, Acute effectAbstract
Linzhi (Ganoderma lucidum) has been used as a medicinal herb continuously for a long time in the treatment of many conditions such as balancing the body, restoring the nervous system, treating diabetes, cancer and hypertension. Previous studies found that the genetically hypertensive rats who received Lingzhi extract continuously for 4-7 weeks has been able to reduce high blood pressure. The aim of the present study was to study the acute effects of Linzhi extract on normotensive condition and the NG-nitro-L-arginine methyl ester (L-NAME) induced hypertension. The study was investigated in both normotensive and hypertensive conditions. Each study, the animals were separated into three groups as control group and Linzhi treated groups (175 and 350 mg/kg, respectively). In hypertensive condition, the animals were injected with L-NAME (10 mg/kg) intravenously to induce hypertension. The hemodynamic parameters such as systolic, diastolic, mean arterial pressures and pulse rate were recorded to compare between experimental groups. It was found that both concentrations of Linzhi extract did not change hemodynamic parameters of normotensive as well as hypertensive animals. Linzhi extract (175 and 350 mg/kg) could not decrease blood pressure in the hypertensive condition induced by L-NAME. Moreover, Linzhi extract did not alter hemodynamic parameters in normotensive animals.
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