Role of probiotics and alteration of the gut microbiota in alzheimer’s disease
Keywords:
Probiotics, Gut Microbiota, Alzheimer’s DiseaseAbstract
Alzheimer’s disease is the most prevalent form of neurodegenerative disorder, primarily affecting the elderly population. This chronic condition is characterized by the progressive destruction of various components of the nervous system. The hallmark pathological features commonly observed in patients include the accumulation of amyloid-beta (Aβ) plaques, the formation of neurofibrillary tangles, and chronic neuroinflammation within the brain. In recent years, there has been growing interest in the use of probiotic supplementation due to its potential health benefits. Probiotics have been shown to support intestinal barrier integrity, enhance immune function, and promote the diversity of gut microbiota. A balanced gut microbiota plays a critical role in maintaining central nervous system homeostasis and modulating neurotransmitter signaling, thereby contributing to improved prognosis in Alzheimer’s disease. Therefore, the present article aims to elucidate the role of probiotics and gut microbiota in modulating neuroinflammation and the pathogenesis of Alzheimer’s disease.
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