Neuroprotective abilities and cognitive enhancing effects of red jasmine rice extract in animal model of Alzheimer’s disease

Authors

  • Wathita Phachonpai Department of Physiology, School of Medical Science, University of Phayao, Phayao Province 56000
  • Jintanaporn Wattanathorn Department of Physiology, Faculty of Medicine, Khonkaen University, Khonkaen Province 40002
  • Terdthai Tong-Un Department of Physiology, Faculty of Medicine, Khonkaen University, Khonkaen Province 40002

Keywords:

Alzheimer’s disease, red jasmine rice, neurodegeneration, antioxidant, cognitive function

Abstract

The aim of the study is to evaluated the neuroprotective effect of the red jasmine rice extract and tested the beneficial effect on memory impairments induced the rat ethylcholine mustard azirinium ion (AF64A) injection model of Alzheimer’s disease. After that the male Wistar rats were supplemented with the red jasmine rice extract at doses of 250 and 500 mg/kg BW once daily continually for 2 weeks. Cognition was evaluated using the Morris water maze test. Both doses of extract supplementation significantly prevented changes of spatial memory of AF64A treated rats. The cognitive enhancement of the extract was found to be related to its ability to inhibit the degeneration of neurons in hippocampus. It is suggested that red jasmine rice extract may prevent the dementia of the Alzheimer type.
vol8No2

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Published

2015-06-17

How to Cite

1.
Phachonpai W, Wattanathorn J, Tong-Un T. Neuroprotective abilities and cognitive enhancing effects of red jasmine rice extract in animal model of Alzheimer’s disease. Health Sci Tech Rev [Internet]. 2015 Jun. 17 [cited 2024 Dec. 22];8(2):67-73. Available from: https://li01.tci-thaijo.org/index.php/journalup/article/view/42595

Issue

Vol. 8 No. 2 (2015): May - August

Section

Research articles

License

ผู้นิพนธ์ต้องรับผิดชอบข้อความในบทนิพนธ์ของตน มหาวิทยาลัยพะเยาไม่จำเป็นต้องเห็นด้วยกับบทความที่ตีพิมพ์เสมอไป ผู้สนใจสามารถคัดลอก และนำไปใช้ได้ แต่จะต้องขออนุมัติเจ้าของ และได้รับการอนุมัติเป็นลายลักษณ์อักษรก่อน พร้อมกับมีการอ้างอิงและกล่าวคำขอบคุณให้ถูกต้องด้วย

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