Neuroprotective effect of Cleistocalyx nervosum var. paniala extract in a rat model of ischemic stroke

Abstract

1 Department of Physiology, School of Medical Science, University of Phayao, Phayao Province 56000
2 Department of Physiology, Faculty of Medicine, Khonkaen University, Khonkaen Province 40002

Stroke is the most common cerebrovascular disease leading to cause of neurological damage, neurological impairment and memory deficits. Oxidative stress plays an important role in brain damage after stroke. Cleistocalyx nervosum var. paniala (C. nervosum), Ma-kiang, is a local plant in northern region of Thailand presenting high antioxidant activity. However, the potential of this extract as the neuroprotection has not been properly investigated. The present study using the rat model of middle cerebral artery occlusion (MCAO), it was found that C. nervosum extract at a dose of 500 mg/kg, administered once daily for 14 days, had markedly improved the neurological behavior performances, decreased the infarct volume, reduced neuronal damage, and improved cognitive
impairment. Overall, C. nervosum extract supplementation may be advantageous to act as neuroprotective agent in ischemic stroke in rat.