Synthesis and Characterization of [Pt (5-acetylamino-1,10-phenanthroline)Cl2]

  • สุพจนี แสนสุข Dr
Keywords: Ligand, Nuclear Magnetic Resonance Spectroscopy, High-Resolution Mass Spectrometry, Complex, Platinum


Synthesis and characterization of [Pt (5-acetylamino-1, 10-phenanthroline)Cl2] were studied, The
reaction between bidentate ligand with Cis-[PtCl2(DMSO)2] were performed by using a reflux at 115 oC,
for 25 hours and at the end of the reaction, the pale-yellow solid with 34% yield was obtained. It has
been characterized by Elemental Analysis, High-Resolution Mass Spectrometry and 1H and 195Pt Nuclear
Magnetic Resonance Spectroscopy.


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Al-Noaimi, M., Awwadi, F. F., Hammoudeh, A., Abu-Hmaid, S. & Bader, R., (2018). Ruthenium complexes of pyridine oxime and azoimine ligands: Syntheses, crystallography, electrochemical and catalytic properties. Inorganica Chimica Acta, 483, 241-247.

Dasari, S. & Tchounwou, P. B. (2014). Cisplatin in cancer therapy: molecular mechanisms of action. European Journal of Pharmacology, 740, 364–378.

Fadeeva, V. P., Tikhova, V. D., & Nikulicheva, O. N., (2008). Elemental Analysis of Organic Compounds with the Use of Automated CHNS Analyzers. Journal of Analytical Chemistry, 63(11), 1094-1106.

Gabano, E., Marengo, E., Bobba, M., Robotti, E., Cassino, C., Botta, M., et al., (2006). 195Pt NMR spectroscopy:
A chemometric approach. Coordination Chemistry Reviews, 250(15-16), 2158-2174.

Jinshui, L., Nan, J., Jing, M., & Xuezhong, D. (2009). Insight into Unusual Downfield NMR Shifts in the Inclusion Complex of Acridine Orange with Cucurbit[7]uril. European Journal of Organic Chemistry, 29, 4931–4938.

Lajer, H. & Daugaard, G. (1999). Cisplatin and hypomagnesemia. Cancer Treatment Reviews, 25(1), 47-58.

Messori, L., & Merlino, A., (2016). Cisplatin binding to proteins: A structural perspective. Coordination Chemistry Reviews, 315, 67-89.

Pleil, J, D., & Isaacs K, K., (2016). High-resolution mass spectrometry: basic principles for using exact mass
and mass defect for discovery analysis of organic molecules in blood, breath, urine and environmental media. Journal of Breath Research, 10, 012001.

Rixe, O., Oryuzar, W., Alvarez, M., Parker, R., Reed, E., Paull, K., et al., (1996). Oxaliplatin, tetraplatin, cisplatin,
and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the national cancer institute’s anticancer drug screen panel. Biochemical Pharmacology, 52(12), 1855-1865.

Wilson, J, J., & Lippard, S. J., (2014). Synthetic Methods for the Preparation of Platinum Anticancer Complexes. Chemical Reviews, 114, 4470-4495.
How to Cite
แสนสุขส. (2019). Synthesis and Characterization of [Pt (5-acetylamino-1,10-phenanthroline)Cl2]. Princess of Naradhiwas University Journal, 11(1), 117-124. Retrieved from