Incidence, risk factors, and mortality rate of patients with Levofloxacin or Trimethoprim-sulfamethoxazole-nonsusceptible Stenotrophomonas maltophilia bacteria at Naradhiwas Rajanagarindra Hospital

Abstract

A five-year retrospective study was conducted from October 1, 2017 to September 30, 2022. Sample of this study was patients from Naradhiwas Rajanagarindra hospital who were older than 15 years old. It was discovered that these patients had a significantly higher incidence of Stenotrophomonas maltophilia bacterium infection (p0.001). According to the findings, the average age of the participants was 57.5 years. 92.8 percent of the subjects have a history of getting antibiotics through vein. The average length of stay in the hospital was 31.6 days. Almost all of them had a respiratory infection (80.5%) and a greater rate of intubation (77.3%) following by a urinary tract infection (7.6%). The most common comorbidity diseases were cerebral vascular disease (21.2), coronary artery disease (17.3), and chronic kidney disease (13.5). Levofloxacin or trimethoprim-sulfametoxasol were the most often utilized antibiotics, with a medication non-susceptibility rate of 19.2%. Prolonged hospital stay was a risk factor for developing medication resistance (p=0.013). Participants who did not acquire drug non-susceptibility had an average hospital stay of 30.5 days, whereas those who did develop drug non-susceptibility had an average hospital stay of 42.4 days. Those with infection who did not acquire non susceptible had a 31% of mortality rate, while those with infection plus drug non susceptible had a 48.7% of mortality rate. As a result, drug non-susceptibility is a significant risk factor for greater mortality rate (p=0.038) and has 1.5 times of the risk factors comparing with participants who do not have drug non-susceptibility.