Phytochemical Screening and Study of Cholesterol Esterase Inhibitory Activity of Extracts from Stem of Dipterocarpus intricatus Dyer

Authors

  • Orapun Jaisamut Faculty of Science and Technology, Rajamangala University of Technology Tawan-OK, Bangpra Campus, Sriracha, Chonburi 20110, Thailand.
  • Sunan Jaisamut Faculty of Science and Technology, Rajamangala University of Technology Tawan-OK, Bangpra Campus, Sriracha, Chonburi 20110, Thailand.
  • Pornnapat Yanpanya Faculty of Pharmaceutical Sciences, Burapha University, Mueang, Chonburi 20131, Thailand.
  • Kronkanok Harinsalai Faculty of Pharmaceutical Sciences, Burapha University, Mueang, Chonburi 20131, Thailand.
  • Supunsa Phuthepkham Faculty of Pharmaceutical Sciences, Burapha University, Mueang, Chonburi 20131, Thailand.
  • Apirak Sakunpak Department of Pharmacognosy, College of Pharmacy, Rangsit University, Mueang, Pathum Thani 12000, Thailand.

Keywords:

Dipterocarpus intricatus Dyer, cholesterol esterase, phytochemical screening, spectroscopic methods

Abstract

Dipterocarpus intricatus Dyer is a medicinal plant used for relieving muscle soreness (bark) and curing wounds (resin). This study investigates chemical composition and cholesterol esterase inhibitory activity of D.intricatus stem harvested from Phrasaeng District, Surat Thani Province, Thailand. Using chromatographic method and spectroscopic analysis, two known compounds, dipterocarpolic acid (1) and bergenin (2), were isolated and identified as a triterpene and a coumarin, respectively. Cholesterol esterase inhibition activity of dipterocarpolic acid (1) and bergenin (2) at concentration of 1.0 mg/mL was 35.22±1.44%, and 42.01±1.65%, respectively, whereas methanolic extract showed activity of 31.70±1.23% at 5.0 mg/mL, compared to orlistat (99.55±0.53%). Therefore, D. intricatus extracts are another alternative for further studies in herbal medicine and natural product development.

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Published

2024-12-17

How to Cite

Jaisamut, O., Jaisamut, S., Yanpanya, P., Harinsalai, K. ., Phuthepkham, S., & Sakunpak, A. (2024). Phytochemical Screening and Study of Cholesterol Esterase Inhibitory Activity of Extracts from Stem of Dipterocarpus intricatus Dyer. Recent Science and Technology, 17(1), 260764. Retrieved from https://li01.tci-thaijo.org/index.php/rmutsvrj/article/view/260764

Issue

Vol. 17 No. 1 (2025): January - April (In progress)

Section

Research Article

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