Preparation, Characterization and Evaluation of Octyl Methoxycinnamate (OMC)-Loaded Solid Lipid Nanoparticles (SLNs) by Using a Microemulsion Technique
Keywords:
Solid lipid nanoparticles (SLNs), Microemulsions, Octyl methoxycinnamate (OMC)Abstract
This research prepared the solid lipid nanoparticles (SLNs) based on microemulsion to load octyl methoxycinnamate (OMC) as a UV absorber for instability protection. The optimal microemulsion formulation was selected by visual assessment according to a transparent and thermodynamically system form. The optimal microemulsion obtained from the experiment composed of 10% w/w glyceryl monostearate (GMS, solid lipid), 10% w/w Tween 80 (surfactant), 15% w/w PEG-40 hydrogenated castor oil (surfactant) and 20% w/w ethanol (co-surfactant). Various processing parameters for the preparation of SLN was carried out using three factors including, 1) warm microemulsion (mL) and iced water ratio (mL), 2) homogenization speed (rpm) and 3) homogenization time (min) and two responses assessed were particle size and polydispersity index (PDI) to obtain a SLNs batch with smaller particle size and optimum PDI. The OMC-loaded SLN had 693.07± 0.05 nm mean particle size and 0.56±0.04 PDI, prepared by optimal processing parameters. The surface morphology of the SLNs was assessed by transmission electron microscopy (TEM), the result found that OMC-loaded SLN showed a smooth surface and spherical shape. Entrapment efficiency of OMC-loaded SLN was found to be 99.89±0.020% . The stability testing of the prepared SLN was studied. Result found that OMC-loaded SLN showed slightly lower stable compared with the initial condition. All obtained results indicated that this method and processing parameters can prepare the SLNs which was suitable for cosmetic application.
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