Utilization of Natural Polymer Wall Materials in Strategies for Health-Effective Lycopene Encapsulation

Authors

  • Yotsinee Huadong School of Culinary Arts, Suan Dusit University, Dusit, Bangkok, 10300 Thailand
  • Tita Foophow School of Culinary Arts, Suan Dusit University, Dusit, Bangkok, 10300 Thailand
  • Thitinat Sukonket Faculty of Science and Technology, Suan Dusit University, Bangkok, 10700 Thailand
  • Weerachon Phoohinkong Faculty of Science and Technology, Suan Dusit University, Bangkok, 10700 Thailand

Keywords:

Lycopene, Natural Polymer, Encapsulation, Inclusion, Complex

Abstract

Natural phytochemical carotenoids, pivotal for human health, enhance wellness, and exhibits anti-aging properties. Lycopene, distinguished by exceptional antioxidant properties, offers protection against oxidative stress. Studied extensively for its potential in medical interventions, it mitigates the risk of diseases like arteriosclerosis and breast cancer. However, lycopene's high antioxidant activity makes it prone to degradation from environmental stresses like oxygen and light, impacting processing and storage. Its water and ethanol insolubility contribute to poor bioavailability. Encapsulation technology addresses these challenges, gaining interest for health benefits in functional foods and cosmeceutical products. The process of lycopene encapsulation, with a specific focus on the selection of diverse wall materials, has demonstrated a substantial impact on both the physical and functional attributes of the encapsulated lycopene within natural biomaterials employed for biomedicine. Natural polymers assume a crucial role in the advancement of biomedicine, nutraceuticals and the functional food industry, particularly in the encapsulation of natural active compounds such as lycopene. Consequently, there is a discernible trend towards the extensive utilization of natural polymers. The choice of a suitable wall material is of paramount importance as it significantly determines the efficacy and success of the encapsulation process. The utilization of natural polymer wall materials presents potential strategies for health-effective lycopene encapsulation. This paper provides a comprehensive overview of lycopene encapsulation, specifically focusing on polysaccharides and proteins, including oligosaccharides and cyclodextrin. The incorporation of these natural polymers in lycopene encapsulation enhances the bioavailability and stability of lycopene, rendering it suitable for diverse biomedical and nutritional applications.

References

Acosta, E. (2009). Bioavailability of nanoparticles in nutrient and nutraceutical delivery. Current Opinion in Colloid & Interface Science, 14(1), 3-15.

Aguirre Calvo, T. R., & Santagapita, P. R. (2017). Encapsulation of a free-solvent extract of lycopene in alginate-Ca(II) beads containing sugars and biopolymers. Chemical and Biological Technologies in Agriculture, 4, 1-8.

Aredo, V., Passalacqua, E. S., Pratavieira, S., & de Oliveira, A.L. (2019). Formation of lycopene-loaded hydrolysed collagen particles by supercritical impregnation. LWT, 110, 158-167.

Augustin, M.A., & Hemar, Y. (2009). Nano-and microstructured assemblies for encapsulation of food ingredients. Chemical Society Reviews, 38(4), 902-912.

Baker, D. L., Krol, E. S., Jacobsen, N., & Liebler, D. C. (1999). Reactions of β-Carotene with cigarette smoke oxidants. identification of carotenoid oxidation products and evaluation of the prooxidant/antioxidant effect. Chemical Research in Toxicology, 12(6), 535-543.

Blanch, G.P., Ruiz del Castillo, M.L., del Mar Caja, M., Pérez-Méndez, M., & Sánchez-Cortés, S. (2007). Stabilization of all-trans-lycopene from tomato by encapsulation using cyclodextrins. Food Chemistry, 105(4), 1335-1341.

Bockuviene, A., Zalneravicius, R., & Sereikaite, J. (2021). Preparation, characterization and stability investigation of lycopene chitooligosaccharides complexes. Food Bioscience, 40, 100854.

Cao-Hoang, L., Phan-Thi, H., Osorio-Puentes, F. J., & Waché, Y. (2011). Stability of carotenoid extracts of gấc(Momordica cochinchinensis) towards cooxidation — Protective effect of lycopene on β-carotene. Food Research International, 44(7), 2252-2257.

Caseiro, M., Ascenso, A., Costa, A., Creagh-Flynn, J., Johnson, M., & Simões, S. (2020). Lycopene in human health. LWT, 127, 109323.

Charpashlo, E., Ghorani, B., & Mohebbi, M. (2021). Multilayered electrospinning strategy for increasing the bioaccessibility of lycopene in gelatin-based sub-micron fiber structures. Food Hydrocolloids, 113, 106411.

Chen, L., Xiang, M., Wu, F., Jiang, Y., Wu, Q., Zhang, W., ... Du, X. (2023). Encapsulation of lycopene into electrospun nanofibers from whey protein isolate-Tricholoma lobayense polysaccharide complex stabilized emulsions: Structural characterization, storage stability, in vitro release, and cellular evaluation. International Journal of Biological Macromolecules, 238, 123993.

de Oliveira, V.E., Almeida, E.W.C., Castro, H.V., Edwards, H.G.M., Dos Santos, H.F., & de Oliveira, L.F.C. (2011). Carotenoids and β Cyclodextrin Inclusion Complexes: Raman Spectroscopy and Theoretical Investigation.

The Journal of Physical Chemistry A, 115(30), 8511-8519.

Đorđević, V., Balanč, B., Belščak-Cvitanović, A., Lević, S., Trifković, K., Kalušević, A., . . . Nedović, V. (2015). Trends in encapsulation technologies for delivery of food bioactive compounds. Food Engineering Reviews, 7(4), 452-490.

dos Santos, P.P., Paese, K., Guterres, S.S., Pohlmann, A.R., Costa, T.H., Jablonski, A., . . . Rios, A.d. O. (2015). Development of lycopene-loaded lipid-core nanocapsules: Physicochemical characterization and stability study. Journal of Nanoparticle Research, 17(2), 107.

Falsafi, S.R., Rostamabadi, H., Babazadeh, A., Tarhan, Ö., Rashidinejad, A., Boostani, S., . . . Jafari, S.M. (2022). Lycopene nanodelivery systems; recent advances. Trends in Food Science & Technology, 119, 378-399.

Fernández-García, E., & Pérez-Gálvez, A. (2017). Carotenoid: β-cyclodextrin stability is independent of pigment structure. Food Chemistry, 221, 1317-1321.

Force, U.S.P.S.T. (2022). Vitamin, mineral, and multivitamin supplementation to prevent cardiovascular disease and cancer: US preventive services task force recommendation statement. JAMA, 327(23), 2326-2333.

Gao, J., Qiu, Y., Chen, F., Zhang, L., Wei, W., An, X., & Zhu, Q. (2023). Pomelo peel derived nanocellulose as Pickering stabilizers: Fabrication of pickering emulsions and their potential as sustained-release delivery systems for lycopene. Food Chemistry, 415, 135742.

Gheonea, I., Aprodu, I., Cîrciumaru, A., Râpeanu, G., Bahrim, G. E., & Stănciuc, N. (2021). Microencapsulation of lycopene from tomatoes peels by complex coacervation and freeze-drying: Evidences on phytochemical profile, stability and food applications. Journal of Food Engineering, 288, 110166.

Ghosh, S., Sarkar, T., Das, A., & Chakraborty, R. (2022). Natural colorants from plant pigments and their encapsulation: An emerging window for the food industry. LWT, 153, 112527.

Ho, K.K. H.Y., Schroën, K., San Martín-González, M.F., & Berton-Carabin, C.C. (2017). Physicochemical stability of lycopene-loaded emulsions stabilized by plant or dairy proteins. Food Structure, 12, 34-42.

Jain, A., Sharma, G., Ghoshal, G., Kesharwani, P., Singh, B., Shivhare, U.S., & Katare, O.P. (2018). Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity. International Journal of Pharmaceutics, 546(1), 97-105.

Jain, S., Winuprasith, T., & Suphantharika, M. (2020). Encapsulation of lycopene in emulsions and hydrogel beads using dual modified rice starch: Characterization, stability analysis and release behaviour during in-vitro digestion. Food Hydrocolloids, 104, 105730.

Jia, C., Cao, D., Ji, S., Lin, W., Zhang, X., & Muhoza, B. (2020). Whey protein isolate conjugated with xylo-oligosaccharides via maillard reaction: Characterization, antioxidant capacity, and application for lycopene microencapsulation. LWT, 118, 108837.

Kha, T.C., Nguyen, M.H., Roach, P.D., & Stathopoulos, C.E. (2015). A storage study of encapsulated gac (Momordica cochinchinensis) oil powder and its fortification into foods. Food and Bioproducts Processing, 96, 113-125.

Komijani, M., Mohebbi, M., & Ghorani, B. (2022). Assembly of electrospun tri-layered nanofibrous structure of zein/ basil seed gum/zein for increasing the bioaccessibility of lycopene. LWT, 161, 113328.

Kusdemir, B.C., Kozgus Guldu, O., Yurt Kilcar, A., & Medine, E.I. (2023). Preparation and in vitro investigation of prostate-specific membrane antigen targeted lycopene loaded niosomes on prostate cancer cells. International Journal of Pharmaceutics, 640, 123013.

Li, H., & Gilbert, R.G. (2018). Starch molecular structure: The basis for an improved understanding of cooked rice texture. Carbohydrate Polymers, 195, 9-17.

Li, N., Wu, X., Zhuang, W., Xia, L., Chen, Y., Wu, C., . . . Zhou, Y. (2021). Tomato and lycopene and multiple health outcomes: Umbrella review. Food Chemistry, 343, 128396.

Li, W., Yalcin, M., Lin, Q., Ardawi, M.-S. M., & Mousa, S.A. (2017). Self-assembly of green tea catechin derivatives in nanoparticles for oral lycopene delivery. Journal of Controlled Release, 248, 117-124.

Li, Y., Cui, Z., & Hu, L. (2023). Recent technological strategies for enhancing the stability of lycopene in processing and production. Food Chemistry, 405, 134799.

Lin, D., Kelly, A. L., & Miao, S. (2022). The impact of pH on mechanical properties, storage stability and digestion of alginate-based and soy protein isolate-stabilized emulsion gel beads with encapsulated lycopene. Food Chemistry, 372, 131262.

Lv, P., Wang, D., Liang, R., Liu, J., Li, J., Gao, Y., . . . Yuan, F. (2021). Lycopene-loaded bilayer emulsions stabilized by whey protein isolate and chitosan. LWT, 151, 112122.

Mele, A., Mendichi, R., & Selva, A. (1998). Non-covalent associations of cyclomaltooligosaccharides (cyclodextrins) with trans-β-carotene in water: Evidence for the formation of large aggregates by light scattering and NMR spectroscopy. Carbohydrate Research, 310(4), 261-267.

Mele, A., Mendichi, R., Selva, A., Molnar, P., & Toth, G. (2002). Non-covalent associations of cyclomaltooligosaccharides (cyclodextrins) with carotenoids in water. A study on the α- and β-cyclodextrin/ψ,ψ-carotene (lycopene) systems by light scattering, ionspray ionization and tandem mass spectrometry. Carbohydrate Research, 337(12), 1129-1136.

Mirahmadi, M., Azimi-Hashemi, S., Saburi, E., Kamali, H., Pishbin, M., & Hadizadeh, F. (2020). Potential inhibitory effect of lycopene on prostate cancer. Biomedicine & Pharmacotherapy, 129, 110459.

Mottiar, Y., & Altosaar, I. (2011). Iodine sequestration by amylose to combat iodine deficiency disorders. Trends in Food Science & Technology, 22(6), 335-340.

Muñoz-Shugulí, C., Vidal, C.P., Cantero-López, P., & Lopez-Polo, J. (2021). Encapsulation of plant extract compounds using cyclodextrin inclusion complexes, liposomes, electrospinning and their combinations for food purposes. Trends in Food Science & Technology, 108, 177-186.

Nerome, H., Machmudah, S., Wahyudiono, Fukuzato, R., Higashiura, T., Youn, Y.-S., . . . Goto, M. (2013). Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation. The Journal of Supercritical Fluids, 83, 97-103.

Pozo, C., Rodríguez-Llamazares, S., Bouza, R., Barral, L., Castaño, J., Müller, N., & Restrepo, I. (2018). Study of the structural order of native starch granules using combined FTIR and XRD analysis. Journal of Polymer

Research, 25(12), 266.

Rocha, G.A., Fávaro-Trindade, C.S., & Grosso, C.R.F. (2012). Microencapsulation of lycopene by spray drying: Characterization, stability and application of microcapsules. Food and Bioproducts Processing, 90(1), 37-42.

Saffarionpour, S. (2019). Nanoencapsulation of hydrophobic food flavor ingredients and their cyclodextrin inclusion complexes. Food and Bioprocess Technology, 12(7), 1157-1173.

Sampaio, G.L.A., Pacheco, S., Ribeiro, A.P.O., Galdeano, M.C., Gomes, F.S., & Tonon, R. V. (2019). Encapsulation of a lycopene-rich watermelon concentrate in alginate and pectin beads: Characterization and stability. LWT, 116, 108589.

Santos, P.D. d.F., Rubio, F.T.V., da Silva, M.P., Pinho, L.S., & Favaro-Trindade, C.S. (2021). Microencapsulation of carotenoid-rich materials: A review. Food Research International, 147, 110571.

Sarko, A., & Wu, H.C.H. (1978). The Crystal structures of A-, B-and C-Polymorphs of amylose and starch. Starch - Stärke, 30(3), 73-78.

Sarko, A., & Zugenmaier, P. (1980). Crystal structures of amylose and its derivatives. In Fiber Diffraction Methods (Vol. 141, pp. 459-482). USA: American Chmical Society.

Sharma, S., Sathasivam, T., Rawat, P., & Pushpamalar, J. (2021). Lycopene-loaded nanostructured lipid carrier from carboxymethyl oil palm empty fruit bunch cellulose for topical administration. Carbohydrate Polymer Technologies and Applications, 2, 100049.

Smaoui, S., Hlima, H.B., Braïek, O.B., Ennouri, K., Mellouli, L., & Khaneghah, A.M. (2021). Recent advancements in encapsulation of bioactive compounds as a promising technique for meat preservation. Meat Science, 181, 108585.

Souza, A.L.R., Hidalgo-Chávez, D.W., Pontes, S.M., Gomes, F. S., Cabral, L.M. C., & Tonon, R.V. (2018). Microencapsulation by spray drying of a lycopene-rich tomato concentrate: Characterization and stability. LWT, 91, 286-292.

Szente, L., & Szejtli, J. (2004). Cyclodextrins as food ingredients. Trends in Food Science & Technology, 15(3), 137-142.

Takehara, M., Nishimura, M., Kuwa, T., Inoue, Y., Kitamura, C., Kumagai, T., & Honda, M. (2014). Characterization and thermal isomerization of (all-E)-Lycopene. Journal of Agricultural and Food Chemistry, 62(1), 264-269.

Tran, T.T.B., Shelat, K.J., Tang, D., Li, E., Gilbert, R.G., & Hasjim, J. (2011). Milling of rice grains. The degradation on three structural levels of starch in rice flour can be independently controlled during grinding. Journal of Agricultural and Food Chemistry, 59(8), 3964-3973.

Zhang, H., Lin, X., Cao, X., Wang, Y., Wang, J., & Zhao, Y. (2024). Developing natural polymers for skin wound healing. Bioactive Materials, 33, 355-376.

Zhang, Y., Zhang, T., Dong, C., Zhao, R., Zhang, X., & Wang, C. (2023). Lycopene-loaded emulsions stabilized by whey protein covalently modified with pectin or/and chlorogenic acid: Enhanced physicochemical stability and reduced bio-accessibility. Food Chemistry, 417, 135879.

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Published

2023-12-18

How to Cite

Huadong, Y. ., Foophow, T. ., Sukonket, T. ., & Phoohinkong, W. . (2023). Utilization of Natural Polymer Wall Materials in Strategies for Health-Effective Lycopene Encapsulation. Journal of Food Health and Bioenvironmental Science, 16(3), 63–74. Retrieved from https://li01.tci-thaijo.org/index.php/sdust/article/view/261895

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