Fasting-mimicking Diets
Keywords:
Fasting-mimicking diets (FMDs) , Restrict diet , NutritionAbstract
Fasting-mimicking diets (FMDs) are designed to replicate the physiological effects of water-only fasting over a period of 5 consecutive days while minimizing the associated burden. By allowing individuals to consume light meals and limiting the fasting period to no more than once a month, FMDs provide a practical alternative to extended fasting. The human FMDs program is plant-based, low in protein and carbohydrates, and high in healthy fats, aimed at achieving fasting-like effects while supplying essential micronutrients (vitamins and minerals) to reduce the burden of fasting. Low protein intake reduces the activity of IGF-1 and mTOR, which are involved in growth and aging. Caloric and nutrient restriction induced by FMDs stimulates autophagy, a cellular cleanup process that removes damaged components and promotes cellular repair. FMDs activate beneficial metabolic and cellular processes that support weight loss, improve metabolic health, reduce inflammation, and enhance tissue regeneration. When implemented properly, FMDs can be a powerful tool for improving overall health and longevity. However, balanced nutrition during the restricted diet is crucial to provide essential nutrients, prevent deficiencies, and support overall health.
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