Comparison of fish skins as alternative biological skin models for skin permeability study

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Published: Dec 29, 2023
DOI: https://doi.org/10.69598/sehs.17.23050016
Keywords:
fish skin trout salmon catfish skin permeation

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Kritsanaporn Tansathien
Department of Pharmaceutical Technology, Faculty of Pharmaceutical sciences, Huachiew Chalermprakiet University, Samut Prakarn, Thailand
Praneet Opanasopit
Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
Prasopchai Patrojanasophon
Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
Mont Kumpugdee-Vollrath
Department of Pharmaceutical and Chemical Engineering, Berliner Hochschule für Technik, Berlin, Germany. Corresponding author's e-mail: vollrath@bht-berlin.de

Abstract

Animal skins are generally used instead of human skin to evaluate drug percutaneous permeation due to ethical and practical reasons. This study aimed to investigate the feasibility of using fish skins, including trout (Salmo trutta), Norwegian salmon (Salmo salar), BIO salmon (Salmo salar), and bighead catfish (Clarias macrocephalus) as alternatives. Caffeine was selected as a model drug. The Franz-diffusion apparatus was used for in vitro skin permeation test, evaluating parameters such as cumulative permeation profile, permeation flux, permeation coefficient, and lag-time. Skin composition was determined using Fourier-transform infrared spectroscopy. The results revealed that bighead catfish skin exhibited the highest cumulative caffeine permeation, while Norwegian salmon skin closely matched the skin permeability parameters of Strat-M®. Based on the permeability parameters and barrier compositions, Norwegian salmon skin demonstrated characteristics similar to Strat-M®.

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How to Cite
Tansathien, K., Opanasopit, P., Patrojanasophon, P., & Kumpugdee-Vollrath, M. (2023). Comparison of fish skins as alternative biological skin models for skin permeability study . Science, Engineering and Health Studies, 17, 23050016. https://doi.org/10.69598/sehs.17.23050016
Issue
Volume 17, 2023
Section
Health sciences
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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