Effect of Acidic Medium on Swelling and Release Behaviors of Chitosan-Reinforced Calcium Pectinate Gel Beads
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Abstract
Chitosan-reinforced calcium pectinate (ChCP) gel beads were prepared by ionotropic gelation method. Theswelling of ChCP gel beads and release behavior of indomethacin from the beads were investigated and comparedwith conventional calcium pectinate (CP) gel beads. The factors, such as molecular weight of chitosan,concentration of chitosan, and release medium, which can have a significant effect on the swelling and releasebehaviors from the beads, were discussed in this study. The mechanical test showed that the ChCP beads haveslightly higher strength than that of CP beads. The swelling index of the ChCP beads in acidic medium was muchlower than that in neutral medium. The release of indomethacin from ChCP beads under conditions mimickingintestinal transit were evaluated in pH 7.4 Tris buffer. The acid pretreatment caused a faster drug release fromChCP beads. The less swelling in acidic medium and faster drug release of acid-pretreated ChCP beads may bedue to the dissolution of chitosan from the beads in acidic medium, as no fluorescence signal was seen at the shellof the beads. The results suggested that the acid, which essentially found in stomach, influenced the swelling andrelease behaviors of ChCP beads.
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