Synthesis, Characterization and In vitro Antibacterial Evaluation of Oxadiazole Derivatives
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Published:
Apr 30, 2017
Keywords:
oxadiazole metal complex antibacterial activity
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Abstract
This research paper reports novel oxadiazole derivatives. Such compounds were prepared and their complexation was performed by treating them with metal salts of Mn(II), Co(II) and Ni(II). The synthesized derivatives were characterized by elemental analysis, IR and electronic spectral studies and magnetic moment studies. Their structures were further supported by 1H NMR spectra. The magnetic behaviour and spectroscopic investigation of complexes indicates mononuclear octahedral structure for complexes. All the derivatives were screened for antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumonia andEscherichia coli. It showed noticeable antibacterial activity.
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How to Cite
Metha, K. (2017). Synthesis, Characterization and In vitro Antibacterial Evaluation of Oxadiazole Derivatives. Science, Engineering and Health Studies, 11(1), 27–35. https://doi.org/10.14456/sustj.2017.3
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Research Articles
References
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Barry, A. L. (1986). Ed. Lorian, V., Procedure for testing antimicrobial agent in agar media: theoretical considerations: antibiotics in laboratory medicine, 2nd ed., Williams & Wilkins, Baltimore.
Ibraheem, H., Adel, H., Ahmed , A., Salih, N., Salimon, J., Graisa, A., Farina, Y., and Yousif, E. (2010). Synthesis, characterization and antimicrobial activity of some metal ions with 2-thioacetic- 5-phenyl-1, 3, 4- oxadiazole. Journal of Al-Nahrain University, 13(1): 43-47.
Jones, R. N., Barry, A. L., Gaven, T. L., and Washington, J. A. (1984). Manual of clinical microbiology, 4th ed., American society for microbiology, Washington DC.
Maslat., A, O., Abussaud, M., Tashtoush, H., and Talib, M, AL. (2002). Synthesis, antibacterial, antifungal and genotoxic activity of Bis-1, 3, 4-oxadiazole derivatives. Polish Journal of Pharmacology, 54: 55-59.
Maslat., A, O., Abussaud, M., Tashtoush, H., and Talib, M, AL. (2002). Synthesis, antibacterial, antifungal and genotoxic activity of Bis-1, 3, 4-oxadiazole derivatives. Polish Journal of Pharmacology, 54: 55-59.
Oruc, E., Rollas, S., Kandemirli, F., Shvets, N., and Dimoglo, A. (2004). 1, 3, 4-thiadiazole derivatives. synthesis, structure elucidation, and structure - antituberculosis activity relationship investigation. Journal of Medicinal Chemistry, 47: 6760-6767.
Parra, M., Hernández, S., and Alderete, J. (2003). Metallomesogens derived from chelating schiffs bases containing 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole: synthesis, characterization and study of mesomorphic properties. Journal of the Chilean Chemical Society, 48(1): 57-60.
Rahmouni, N., T. Djebbar, S., Chenah, N., and Benali-Baitich, O. (1999). Synthesis, characterization and electrochemical behaviour of some manganese and copper complexes with tetradentate schiff base ligands. Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 29(6): 979-994.
Vogel, A. I. (2004). Revised by Jeffery, G. H., Bassett, J., Mendham, J., and Denney, R. C, Textbook of Quantitative Chemical Analysis, 6th ed., Pearson, New Delhi.
Xia, Y., Yang, Z. Y., Hour, M. J., Kuo, S. C., Xia, P., Bastow, K. F., Nakanishi, Y., Nampoothiri, P., Hackl, T., Hamel, E., and Lee, H. K. (2001). Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-arylquinazolinones. Bioorganic and Medicinal Chemistry Letters, 11(9): 1193-1196.
Yang, G. F., Liu, Z. M., and Qing, X. H. (2001). Synthesis of 5, 7-dimethyl-2- (5-substituted-1, 3, 4-oxadiazole-2-yl) -methylenethio-1, 2, 4- triazolo[1,5-a] pyrimidines as potential fungicides, Chinese Chemical Letters, 12(10): 877-880.
Zarghi, A., Tabatabai, S. A., and Faizi Ahadian, A. (2005). Synthesis and anticonvulsant activity of new 2 substituted benzyloxyphenyl-1, 3, 4- oxadiazoles. Bioorganic Letters, 15: 1863-1865.
Zheng, X., Li, Z., Wang, Y., Chen, W., Huang, Q., Liu, C., and Song, G. (2003). Synthesis and insecticidal activities of novel 2, 5-disubstituted 1, 3, 4-oxadiazoles. Journal of Fluorine Chemistry, 123: 163-169.