การประยุกต์ทางเวชสำอางของน้ำมันหอมระเหยว่านสาวหลงจากส่วนทั้งต้นและส่วนใต้ดิน

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อรรถพล อุทัยเรือง
รุจิลักขณ์ รัตตะรมย์
คัทลียา เมฆจรัสกุล

Abstract

Wansaolong or Amomum biflorum Jack belongs to family of Zingiberaceae. Every parts of plant have a unique aroma. Nowadays, its essential oils have been utilized. However, there are a few studies regarding its pharmacological activities. There are also no reports to support which part of plant is suitable for product development. The aim of this study was to investigate the biological activities and chemical constitutions of A. biflorum Jack essential oils from whole plant and rhizomes. Essential oils were prepared by water distillation technique. The chemical constitutions were identified by using gas chromatography-mass spectrometry. Antioxidant activities were determined by using 2,2-diphenyl-1-picrylhydrazyl and ferric ion reducing antioxidant power assay. Dopachrome method was used for determination of anti-tyrosinase activity. Anti-Cutibacterium acnes activity was studied by using agar diffusion method and broth microdilution methods. The results showed that 1-[(E)-but-1-enyl]-4-methoxybenzene was found as a major constituent in the essential oils of both whole plant and rhizomes. The essential oils from two parts exhibited anti-tyrosinase activities with IC50 values of 117.94±19.08 and 147.03±10.28 µg/mL, respectively, with no significant difference between two parts. They showed minimum inhibitory and minimal bactericidal concentrations at 75 µg/mL against C.acnes. Antioxidant effects of the essential oils showed lower activities than that of α-tocopherol and ascorbic acid. Therefore, A. biflorum essential oils from whole plant and rhizomes have a potential to develop as the cosmeceutical products for skin whitening and anti-acnes applications.

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Section
วิทยาศาสตร์ชีวภาพ
Author Biographies

อรรถพล อุทัยเรือง

คณะเภสัชศาสตร์ มหาวิทยาลัยมหาสารคาม ตำบลขามเรียง อำเภอกันทรวิชัย จังหวัดมหาสารคาม 44150

รุจิลักขณ์ รัตตะรมย์

คณะเภสัชศาสตร์ มหาวิทยาลัยมหาสารคาม ตำบลขามเรียง อำเภอกันทรวิชัย จังหวัดมหาสารคาม 44150

คัทลียา เมฆจรัสกุล

คณะเภสัชศาสตร์ มหาวิทยาลัยมหาสารคาม ตำบลขามเรียง อำเภอกันทรวิชัย จังหวัดมหาสารคาม 44150

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