Osteoblast Proliferation with Andrographolide and the Development of Debittering Taste of Andrographis Tea Leaf
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Abstract
Isolated andrographolide from the crude acetone extract of Andrographis paniculata leaves promoted osteoblast cell lines proliferation with 152.9±8.6% of cell viability at concentration of 100 µg/mL which was better than that of the control (100±7.1 %). Moreover, at the high concentration of andrographolide (100 µg/mL), it exhibited no cytotoxic against osteoblast cell lines. Therefore, this research aimed to develop a bitter tasted reducing by adding the different types of taste into Andrographis tea to yield 7 tea formulas to improve the taste that was more acceptable from consumers. The tea formula 3 with Tahiti’s juice added, significantly showed the best reduction the bitterness of Andrographis tea at 95 % confidence interval. From the results of this research, it reveals that Tahiti’s juice-added Andrographis tea can be developed to apply for osteoporosis prevention.
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