องค์ประกอบทางเคมีจากกิ่งสะทอน
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เผยแพร่แล้ว:
ม.ค. 19, 2020
คำสำคัญ:
สะทอน ไตรเทอร์พีน สเตอรอยด์
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บทคัดย่อ
นำกิ่งสะทอน (Millettia utilis Dunn.) มาสกัดด้วยตัวทำละลายไดคลอโรมีเทน แล้วนำส่วนสกัดหยาบไปแยกด้วยเทคนิคคอลัมน์โครมาโทกราฟี โดยใช้ซิลิกาเจลเป็นตัวดูดซับและชะด้วยตัวทำละลายเฮกเซน ไดคลอโรมีเทน เอทิลแอซีเตท และเมทานอล พบว่าได้สารบริสุทธิ์ 3 ชนิด จากนั้นนำไปวิเคราะห์หาโครงสร้างด้วยเทคนิคนิวเคลียร์แมกเนติกเรโซแนนซ์สเปกโทรสโกปี และเปรียบเทียบกับสารที่เคยมีการรายงานมาแล้ว เพื่อหาสูตรโครงสร้างสำหรับสารประกอบทั้ง 3 ชนิด พบว่าสารชนิด 1 และ 2 เป็นสารไตรเทอร์พีน (erythrodiol และ lupeol ตามลำดับ) ส่วนสาร 3 เป็นสารสเตอรอยด์ (stigmasterol)
Article Details
ประเภทบทความ
Physical Sciences
เอกสารอ้างอิง
[1] Temsirireagkul, R., Saraya, S., Wongkrachang, Y., Ruangwiset, N. and Chuokul, W., 2005, A Project to Study Preservatives from Herbs to Extend the Product of Community Chili Paste, Department of Pharmacy, Faculty of Pharmacy Mahidol University, Bangkok, 50 p. (in Thai)
[2] Huo, X., Zhang, L., Gao, L., Guo, Y., Zhang, L., Li, L., Si., J. and Cao, L., 2015, Antiinflammatory and analgesic activities of ethanol extract and isolated compounds from Millettia pulchra, Biol. Pharm. Bull. 38: 1328-1336.
[3] Kamto, E.D., Atchade, A.T., Marston, A., Pegnyemb, E.D. and Westhuizen, J.H., 2012, Chemical constituents from bark of Millettia mannii Baker (Papilionoideae-Leguminosae), Biochem. Syst. Ecol. 45: 98-101.
[4] Derese, S., Barasa, L., Akala, H.M., Yusuf, A.O., Kamau, E., Heydenreich, M. and Yenesew, M., 2014, 4-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species, Phytochem. Lett. 8: 69-72.
[5] Sritularak, B. and Likhitwitayawuid, K., 2006, Flavonoids from the pods of Millettia erythrocalyx, Phytochemistry 67: 812-817.
[6] Pancharoen, O., Athipornchai, A., Panthong, A. and Taylor, W.C., 2008, Isoflavones and Rotenoids from the Leaves of Millettia brandisiana, Chem. Pharm. Bull. 56: 835-838.
[7] Phrutivorapongkul, A., Lipipun, V., Ruangrungsi, N., Kirtikara, K., Nisikawa, K., Maruyama, S., Watanabe, T. and Ishikawa, T., 2003, Studies on the chemical constituents of stem bark of Millettia leucantha: Isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities, Chem. Pharm. Bull. 51: 187-190.
[8] Abbass, H.M., Ragab, E.A., Mohammed, A.E. and El-hela, A.A., 2015, Phyto chemical and biological investigations of Ficus mysorensis cultivated in Egypt, J. Pharm. Chem. Biol. Sci. 3: 396-407.
[9] Aktar, F., Kaisar, M.A., Kabir, A.H., Hasan, C.M. and Rashid, M.A., 2009, Phyto chemical and biological investigations of Ixora arborea Roxb, J. Phram. Sci. 8: 161-166.
[10] Wang, F., 1H-NMR Spectra of Common Triterpenoids (18 Compounds), Available Source: https://www.wangfei.ac.cn/article/nmrspectra/7/1/35, July 9, 2018.
[11] Laghari, A.H., Memon, S., Nelofar, A. and Khan, K.M., 2011, Alhagi maurorum: A convenient source of lupeol, Ind. Crops Prod. 34: 1141-1145.
[12] Kolak, U., Topcu, G., Birteksoz, S., Otuk, G. and Ulubelen, A., 2005, Terpenoids and steroids from the roots of Salvia blepha ronchlaena, Turk. J. Chem. 29: 177-186.
[13] Forgo, P. and Kover, K.E., 2004, Gradient enhanced selective experiments in the 1H NMR chemical shift assignment of the skeleton and side-chain resonances of stigmasterol, a phytosterol derivative, Steroids 69: 43-50.
[14] Douglas, K., Kiplimo, J.J. and Chirchir, D., 2016, Phytochemistry and antibacterial activity of extracts from medicinal plant Olea africana, Afr. J. Pharm. Pharmacol. 10: 330-336.
[15] Kangsamaksin, T., Chaithongyot, S., Woot thichairangsan, C., Hanchaina, R., Tangshewinsirikul, C. and Svasti, J., 2017, Lupeol and Stigmasterol Suppress Tumor Angio genesis and Inhibit Cholangiocarcinoma Growth in Mice via Downregulation of Tumor Necrosis Factor-, Available Source: https://journals.plos.org/plosone/ article?id=10.1371/journal.pone.0189628, July 19, 2018.
[16] Gallo, M.B.C. and Sarachine, M.J., 2009, Biological activities of lupeol, Int. J. Biomed. Pharm. Sci. 3(spec.): 46-66.
[2] Huo, X., Zhang, L., Gao, L., Guo, Y., Zhang, L., Li, L., Si., J. and Cao, L., 2015, Antiinflammatory and analgesic activities of ethanol extract and isolated compounds from Millettia pulchra, Biol. Pharm. Bull. 38: 1328-1336.
[3] Kamto, E.D., Atchade, A.T., Marston, A., Pegnyemb, E.D. and Westhuizen, J.H., 2012, Chemical constituents from bark of Millettia mannii Baker (Papilionoideae-Leguminosae), Biochem. Syst. Ecol. 45: 98-101.
[4] Derese, S., Barasa, L., Akala, H.M., Yusuf, A.O., Kamau, E., Heydenreich, M. and Yenesew, M., 2014, 4-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species, Phytochem. Lett. 8: 69-72.
[5] Sritularak, B. and Likhitwitayawuid, K., 2006, Flavonoids from the pods of Millettia erythrocalyx, Phytochemistry 67: 812-817.
[6] Pancharoen, O., Athipornchai, A., Panthong, A. and Taylor, W.C., 2008, Isoflavones and Rotenoids from the Leaves of Millettia brandisiana, Chem. Pharm. Bull. 56: 835-838.
[7] Phrutivorapongkul, A., Lipipun, V., Ruangrungsi, N., Kirtikara, K., Nisikawa, K., Maruyama, S., Watanabe, T. and Ishikawa, T., 2003, Studies on the chemical constituents of stem bark of Millettia leucantha: Isolation of new chalcones with cytotoxic, anti-herpes simplex virus and anti-inflammatory activities, Chem. Pharm. Bull. 51: 187-190.
[8] Abbass, H.M., Ragab, E.A., Mohammed, A.E. and El-hela, A.A., 2015, Phyto chemical and biological investigations of Ficus mysorensis cultivated in Egypt, J. Pharm. Chem. Biol. Sci. 3: 396-407.
[9] Aktar, F., Kaisar, M.A., Kabir, A.H., Hasan, C.M. and Rashid, M.A., 2009, Phyto chemical and biological investigations of Ixora arborea Roxb, J. Phram. Sci. 8: 161-166.
[10] Wang, F., 1H-NMR Spectra of Common Triterpenoids (18 Compounds), Available Source: https://www.wangfei.ac.cn/article/nmrspectra/7/1/35, July 9, 2018.
[11] Laghari, A.H., Memon, S., Nelofar, A. and Khan, K.M., 2011, Alhagi maurorum: A convenient source of lupeol, Ind. Crops Prod. 34: 1141-1145.
[12] Kolak, U., Topcu, G., Birteksoz, S., Otuk, G. and Ulubelen, A., 2005, Terpenoids and steroids from the roots of Salvia blepha ronchlaena, Turk. J. Chem. 29: 177-186.
[13] Forgo, P. and Kover, K.E., 2004, Gradient enhanced selective experiments in the 1H NMR chemical shift assignment of the skeleton and side-chain resonances of stigmasterol, a phytosterol derivative, Steroids 69: 43-50.
[14] Douglas, K., Kiplimo, J.J. and Chirchir, D., 2016, Phytochemistry and antibacterial activity of extracts from medicinal plant Olea africana, Afr. J. Pharm. Pharmacol. 10: 330-336.
[15] Kangsamaksin, T., Chaithongyot, S., Woot thichairangsan, C., Hanchaina, R., Tangshewinsirikul, C. and Svasti, J., 2017, Lupeol and Stigmasterol Suppress Tumor Angio genesis and Inhibit Cholangiocarcinoma Growth in Mice via Downregulation of Tumor Necrosis Factor-, Available Source: https://journals.plos.org/plosone/ article?id=10.1371/journal.pone.0189628, July 19, 2018.
[16] Gallo, M.B.C. and Sarachine, M.J., 2009, Biological activities of lupeol, Int. J. Biomed. Pharm. Sci. 3(spec.): 46-66.
