Development of Natural Anti-acne Patch from Biocellulose Formulated with Dracaena cochinchinensis (Lour.) S.C. Chen Crude Extract -
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Abstract
This study aimed to analyze antioxidant activity, total phenolic and flavonoid contents of Dracaena cochinchinensis (Lour.) S.C. Chen extracts (Chandaeng) and develops a natural anti-acne patch from bio-cellulose formulated with Chandaeng and then tests anti-acne inducing bacterial activity. The antioxidant activity of Chandaeng (15 mg/mL) was 97.01±0.10 %. Total phenolic and flavonoid contents were 4796.44±217.06 mg GAE/mL of gel formulated with crude extract and 667.39±40.11 mg catechin/g crude extract. The natural anti-acne patch from bio-cellulose was formulated with Chandaeng concentrations at 5 (F1), 10 (F2), and 15 (F3) mg/mL. Antibacterial activity was tested with three bacterial strains, i.e., Staphylococcus aureus ATCC25923, Staphylococcus epidermidis TISTR518, and Cutibacterium acnes DMST14916. The results showed that the anti-acne patch (F3) had the highest activities against C. acnes DMST14916 with an inhibition zone at 25.17±1.26 mm. The antibacterial activity of anti-acne patch (F3) was stable after one month of storage. In conclusion, a natural anti-acne patch from bio-cellulose formulated with Chandaeng has high potential in anti-acne inducing antibacterial activity and high antioxidant activity.
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