Antibacterial susceptibility of Proteus mirabilis from canine urine to fosfomycin

Abstract

Proteus mirabilis is one of the most common bacterial pathogens in canine urinary tract infection (UTI). Fosfomycin is a bactericidal drug with broad spectrum. Fosfomycin is suitable for an alternative drug for UTI treatment due to its high concentration in urine, as well as its high efficacy against most uropathogens. The propose of this study was to investigate the susceptibility of Proteus mirabilis from canine urine to fosfomycin. The results showed fosfomycin susceptibility rate at 80.9 % and MIC range from 0.125 to >1024 µg/mL. MIC50 and MIC90 values were 6 and 128 µg/mL, respectively. To compare with percent susceptibility to other antibacterial drugs, fosfomycin susceptibility in this study was higher than those of amoxicillin/clavulanic acid (78.7) and trimethoprim/ sulfamethoxazole (46.8). These findings may be the consequences from rarely use of fosfomycin in veterinary practice, leading to the lower resistant rates than those of other commonly used antibacterial drugs. From this study, it is suggested that fosfomycin is a good alternative drug for UTI treatment in dogs, or in combination with other antibacterial drugs to enhance the antibacterial efficacy and delay bacterial resistance. Bacterial culture and antibacterial susceptibility testing should be performed before selecting the appropriate antibacterial drug.