Treatment of Acne with Topical Patch Containing Tacca Chantrieri Extract: an Open-Label Study

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Published: Feb 23, 2018
Keywords:
Topical patch Tacca chantrieri acne inflammation clinical trial

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Shisanupong Anukanon
School of Medicine, Mae Fah Luang University, Chiang Rai, THAILAND
Chaiyong Rujjanawate
School of Medicine, Mae Fah Luang University, Chiang Rai, Thailand

Abstract

Tacca chantrieri André is a perennial plant with a cylindrical rhizome. Previous pre-clinical studies revealed that an ethanolic extract of this plant’s rhizome exerts many pharmacological actions, including anti-inflammatory and antimicrobial activities, which make it suitable for acne treatment. In this study, a topical patch incorporating 2% w/w of ethanol extract of Tacca chantrieri André’s rhizomes was evaluated for clinical efficacy and safety, in 30 participants with non-inflammatory or inflammatory acne. An open-label, without a comparator study, was conducted for a period of 6 weeks. The results showed that participants with all grades of Acne Global Severity Scale (AGSS) had a reduction in the severity of their acne. The success rate of treatment was 65.52%. There were no adverse reactions in any of these participants. Our data showed that a topical patch containing an ethanol extract of Tacca chantrieri André’s rhizome can be a useful treatment of acne.

Article Details

Issue
Vol. 40 No. 1 (2018): Thai Journal of Pharmacology
Section
Research Articles

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