Fimasartan, a New Angiotensin II Receptor Blocker for Hypertension

Main Article Content

Pornpun Vivithanaporn
Sirada Sihirun


Fimasartan, an angiotensin II receptor blocker (ARB), is approved for treatment of hypertension. This drug has higher potency and longer duration than losartan. The use of 60 to 120 mg of fimasartan once daily is able to control blood pressure for 24 h. The efficacy of fimasartan in reducing blood pressure is not inferior to that of candesartan but fimasartan provides greater effect than losartan and valsartan. The combination of fimasartan with hydrochlorothiazide or amlodipine increases blood pressure reduction. The most common adverse effects of fimasartan are headache and dizziness. Fimasartan is mainly excreted in bile. The hepatic uptake of fimasartan is dependent on organic anion-transporting polypeptide (OATP)1B1 transporters, thus causing drug-drug interaction when used in combination with OATP1B1 substrates such as rifampicin and atorvastatin. In addition to anti-hypertensive effect, preclinical studies in cell culture and animal models demonstrated the anti-inflammatory effect of fimasartan, which is related to cardioprotective and neuroprotective effects on ischemic injury as well as renoprotective and anti-atherosclerotic effect. The clinical studies in Korean patients found that fimasartan was beneficial for vascular function in patients with stroke and increased glucose-dependent insulin secretion in type 2 diabetic patients.



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Review Articles
Author Biography

Pornpun Vivithanaporn, Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand

Research Publications

  1. Acharjee S., Branton W.G., Vivithanaporn P., Maingat F., Paul A., Dickie P., Baker G.B., Power C. (2014) HIV-1 Nef expression in microglia disrupts dopaminergic and immune functions with associated mania-like behaviors. Brain Behav Immun. 40:74-84. (Q1 in Immunology and in Neurosciences, IF 2012 = 5.612)
  2. Ontawong A., Saowakon N., Vivithanaporn P., Pongchaidecha A., Lailerd N., Amornlerdpison D., Lungkaphin A. and Srimaroeng C. (2013) Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats. Biomed Research International. Article ID 820786, 15 pages. doi:10.1155/2013/820786. (Q2 in Medicine, Research and Experimental, IF 2012 = 2.880, Formerly known as Journal of Biomedicine and Biotechnology)
  3. Polyak M.J., Vivithanaporn P., Maingat F.G., Walsh J.G., Branton W., Cohen E.A., Meeker R. and Power C. (2013) Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence. FASEB Journal. 27(7): 2829-44. (Q1 in Biochemistry and molecularbiology, in Biology, in Cell Biology, IF 2012 = 5.704)
  4. Maingat F.G., Polyak M.J., Paul A.M., Vivithanaporn P., Noorbakhsh F., Ahboucha S., Baker G.B., Pearson K. and Power C. (2013) Neurosteroid-mediated regulation of brain innate immunity in HIV/AIDS: DHEA-S suppresses neurovirulence. FASEB Journal. 27(2): 725-37. (Q1 in Biochemistry and molecularbiology, in Biology, in Cell Biology, IF 2012 = 5.704)
  5. McCombe JA., Vivithanaporn P., Gill M. and Power C. (2013) Predictors of symptomatic HIV-associated neurocognitive disorders in universal health care. HIV Medicine. 14(2): 99-107. (Q2 in Infectious Disease, IF 2012 = 3.324)
  6. Power C.*, Hui E., Vivithanaporn P., Acharjee S. and Polyak M. (2012) Delineating HIV-associated neurocognitive disorders using transgenic models: the neuropathogenic actions of Vpr. Journal of Neuroimmune Pharmacology. 312(1-2):45-51. (Q1 in Pharmacology and Pharmacy, IF 2012 = 3.802)
  7. Vivithanaporn P., Nelles K., DeBlock L., Newman S.C., Houston S., Gill M.J. and Power C.* (2012) Hepatitis C virus coinfection increases neurological disease burden and risk of death in treated NeuroAIDS. Journal of the Neurological Sciences. 312(1-2): 45-51. (Q2 in Clinical Neurology, IF 2011 = 2.243)
  8. Vivithanaporn P.*, Gill M.J., Power C. (2011) Impact of current antiretroviral therapies on neuroAIDS. Expert Review of Anti-infective Therapy. 9(4): 371-4. (Q1 in Pharmacology and Pharmacy, IF 2011 = 3.283)
  9. Na H., Acharjee S., Jones G., Vivithanaporn P., Noorbakhsh F., Barsby N., Maingat F., Ballanyi K., Pardo C., Cohen E.A. and Power C.* (2011) Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence. Retrovirology. 8: 44. (Q1 in Virology, IF 2011 = 6.470)
  10. Vivithanaporn P., Maingat F., Lin L.T., Na H., Richardson C.D., Agrawal B., Cohen E.A., Jhamandas J.H. and Power C. (2010) Hepatitis C virus core protein induces neuroimmune activation and potentiates human immunodeficiency virus-1 neurotoxicity. PLoS ONE. 5(9). pii: e12856. (Q1 in Biology, IF 2010 = 4.411)
  11. Vivithanaporn P., Heo G., Gamble J., Krentz H.B., Hoke A., Gill M.J. and Power C.* (2010) Neurologic disease burden in treated HIV/AIDS predicts survival: a population-based study. Neurology. 75(13):1150-8. (Q1 in Clinical Neurology, IF 2010 = 8.017)
  12. Lee K.+, Vivithanaporn P.+, Siemieniuk R., Krentz H.B., Maingat F., Gill M.J. and Power C.* (2010) Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS. BMC Neurology. 10:44. (Q2 in Clinical Neurology, IF 2010 = 2.797)
  13. + Both authors contributed equally to this study.
  14. Maingat F., Viappiani S., Zhu Y., Vivithanaporn P., Ellestad K.K., Holden J., Silva C. and Power C.* (2010) Regulation of Lentivirus neurovirulence by lipopolysaccharide conditioning: suppression of CXCL10 in the brain by IL-10. Journal of Immunology. 184(3):1566-74. (Q1 in Immunology, IF 2010 = 5.745)
  15. Maingat F., Vivithanaporn P., Zhu Y., Taylor A., Baker G., Pearson K. and Power C.* (2009) Neurobehavioral performance in feline immunodeficiency virus infection: integrated analysis of viral burden, neuroinflammation, and neuronal injury in cortex. Journal of Neuroscience. 29(26):8429-37. (Q1 in Neuroscience, IF 2009 = 7.178)
  16. Gill M.B., Vivithanaporn P. and Swanson G.T.* (2009) Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis. Journal of Biological Chemistry. 284(2ปร1):14503-12. (Q1 in Biochemistry & Molecular Biology, IF 2009 = 5.328)
  17. Vivithanaporn P., Lash L.L., Marszalec W. and Swanson G.T.* (2007) Critical roles for the M3-S2 transduction linker domain in kainate receptor assembly and postassembly trafficking. Journal of Neuroscience. 27(39): 10423-33. (Q1 in Neuroscience, IF 2007 = 7.490)
  18. Vivithanaporn P., Yan S. and Swanson G.T.* (2006) Intracellular trafficking of KA2 kainate receptors mediated by interactions with coatomer protein complex I (COPI) and 14-3-3 chaperone systems. Journal of Biological Chemistry. 281(22): 15475-84. (Q1 in Biochemistry & Molecular Biology, IF 2006 = 5.808)


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