Comparative Effectiveness of Oral Astaxanthin Given Daily VS. Every Other Day on Skin Elasticity: Randomized, Double-Blind Cohort Research

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Prasan Chiewprasit
Pongsiri Koonngam


Astaxanthin is an excellent antioxidant known as the “king of antioxidants”. Many clinical studies have shown that astaxanthin helps delay skin ageing. Astaxanthin also has a long half-life, so astaxanthin does not necessarily have to be taken daily. However, there is no clinical study to prove this idea. Thus, 49 healthy Thai females were recruited and treated with astaxanthin at 4 mg daily or astaxanthin at 4 mg every other day for eight weeks. All volunteers were tested for the following four skin properties: elasticity, moisture, TEWL, and melanin index by using a Cutometer, Corneometer, TEWAmeter and Mexameter. The satisfaction of the volunteers was also assessed at the first visit and eight weeks after taking astaxanthin.  Both groups showed significant improvements in skin elasticity after eight weeks, and there were no differences in the increase in skin elasticity of either group. Skin moisture was improved in the group taking astaxanthin daily (p=0.003) and showed a tendency for improvement in the group taking astaxanthin every other day (p=0.052). TEWL and the melanin index were not statistically improved in either group. These results demonstrate that taking astaxanthin every other day could significantly improve skin elasticity, with no difference compared to taking astaxanthin daily. Furthermore, taking astaxanthin every other day tended to enhance skin moisture content.


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