Anti-Proliferative and Apoptotic Effects of Ethanolic Extracts of the Seaweed Caulerpa lentillifera Against Human Glioblastoma Cells
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Abstract
Caulerpa lentillifera (CL), or sea grapes, is a widely consumed as food in Asia. Our previous study showed the anti-proliferative and apoptosis effects of the hexane extract of this seaweed. We investigated the effects of the ethanolic extract of this seaweed (CLET) on the in vitro proliferation and apoptotic cell death in A172 human glioblastoma cells using MTT, CFSE, and Annexin V-FITC assays. CLET at 500 µg/ml reduced A172 cell viability by inducing apoptotic cell death, while lower concentrations of CLET reduced proliferation of A172 cells. The present study suggests that CLET could inhibit proliferation and promote apoptotic cell death in human GBM cells, suggesting its potential to be used as an alternative treatment for glioblastoma.
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