Evaluation of Long Cuff Nitrile Examination Gloves’ Resistance to Chemotherapy Drug Permeation

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Withaya Chanchai
Nipaporn Auttanate
Jitkanya Promnongsaen
Songsit Srisua


Nitrile examination gloves with a long cuff are frequently used in healthcare settings considering their superior durability and resistance to punctures, tears, and chemicals. Many toxic substances, including chemotherapy medications, can be effectively protected against by wearing nitrile gloves. Following established standards, this study evaluated long-cuff nitrile gloves against chemotherapy drug permeation. These tests involved exposing the gloves to 11 different chemotherapy drugs and measuring the permeation rate over a specified duration. Powder-free nitrile exam gloves and extended cuff methods of chemical analysis with regards to standard practice permeation testing for assessing the resistance of medical gloves to permeation by chemotherapy drugs (ASTM D 6978-05) The EN455 Part 1: 2000 were used to test for single-use medical gloves. The testing of chemotherapy drugs and UV/NIS absorption spectrometry were used to measure the absorbance of test chemicals, testing how much of each chemical permeated through the specimens into the collection medium. The collection medium was circulated in a closed loop at an 11 ml/minute flow rate through the testing period. It is clear that glove users must protect against the specific chemicals or chemical mixtures they are exposed to during chemotherapy. However, the results show that long cuff 400mm full finger textured 6mil nitrile gloves protected against chemotherapy drugs during working at the point of use.

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Chanchai W, Jindarat C. Comparative double-blind study of efficacy of pre-cleaners for surgical instruments and medical devices in the central sterile services department. J Biomed Res Environ Sci. 2022;3(9):1122-1127.

Chanchai W, Jindarat C, Suksawat P, Nacglud R, Kasemsan T, Promsorn N. Effectiveness of instrument pre-cleaning and disinfection sprays against the microbial burden and blood stains remover on medical device. J Surg. 2022;7(16):1-5

Jariyapongpaiboon S, Pinprayoon O, Onjun O. A comparison study of physical properties of dental dam, latex examination gloves and nitrile examination gloves: tensile strength, elongation and tear strength properties. J Dms. 2020;45(3):82-89.

Preece D, Lewis R, Carre M.J. A critical review of the assessment of medical gloves. Tribol-Mater Surf Interfaces. 2021; 15(1):10-19.

Tinsley D, Chadwick RG. The permeability of dental gloves following exposure to certain dental materials. J Dent. 1997;25: 65-70.

Edlich RF, Woodard CR, Hill LG, Heather CL. Latex allergy: a life threatening epidemic for scientists, healthcare personnel, and their patients. J Long Term Eff Med Implants. 2003;13:11-19.

Mast ST, Woolwine JD, Gerberding JL. Efficacy of gloves in reducing blood borne volumes transferred during simulated needlestick injury. J Infect Dis. 1993;168: 1589-1592.

ASTM D3578 – 05. Standard Specification for Rubber Examination Gloves. 2015.

ASTM D6319 – 10. Standard Specification for Nitril Examination Gloves for Medical Application. 2015.

ASTM D624 – 00. Standard Test Method for Tear Strength of Conventional Vulcanized Rubber and Thermoplastic Elastomers. 2012.

ISO 11193-1. Single-use medical examination gloves-Part1: Specification for gloves made from rubber latex or rubber solution. 2008.

World Health Organization. Technical Specifications of Personal Protective Equipment for COVID-19: Interim Guidance. 2020.

Kimtech Brand. Kimberly-Clark Nitrile Gloves Chemical Resistance Guide [Internet]. 2009 [cited 2020 Jan 10]. Available from: http://www.kimtech.com/nitrilechemicalresistanceguide/K2365_09_01_SN%20Chem%20Guide_v10.pdf

Shless JS, Crider YS, Pitchik HO, Qazi AS, Styczynski A, LeMesurier R, et al. Physical integrity of medical exam gloves with repeated applications of disinfecting agents: evidence for extended use. medRxiv. 2021:2021.05.31.21258129.

Kampf G, Scheithauer S, Lemmen S, Saliou P, Suchomel M. COVID-19-associated shortage of alcohol-based hand rubs, face masks, medical gloves, and gowns: proposal for a risk-adapted approach to ensure patient and healthcare worker safety. J Hosp Infect. 2020;105(3): 424–427.

Ahmed J, Malik F, Arif TB, Majid Z, Chaudhary MA, Ahmad J, et al. Availability of personal protective equipment (ppe) among US and Pakistani doctors in COVID-19 pandemic. Cureus. 2020;12(6): e8550.

Centers for Disease Control and Prevention. Strategies for Optimizing the Supply of Disposable Medical Gloves [Internet]. 2020 [cited 2020 Nov 2]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/ hcp/ppe-strategy/gloves.html

Chang J, Jeong TD, Lee S, Kim Y, Lee J, Lee HK, et al. Intactness of medical nonsterile gloves on use of alcohol disinfectants. Ann Lab Med. 2018;38(1): 83–84.

Gao P, Horvatin M, Niezgoda G, Weible R, Shaffer R. Effect of multiple alcohol-based hand rub applications on the tensile properties of thirteen brands of medical exam nitrile and latex gloves. J Occup Environ Hyg. 2016;13(12):905–914.

Hunt LW, Fransway AF, Reed CE, Miller LK, Jones RT, Swanson MC, et al. An epidemic of occupational allergy to latex involving healthcare workers. J Occup Environ Med. 1995;37:1204-1209.

Baid R, Agarwal R. Reply to letter to editor regarding the article, “powdered gloves: time to bid adieu. J Postgrad Med. 2018; 64(1):68.

US Food and Drug Administration. Medical Glove Guidance Manual: Guidance for Industry and FDA Staff [Internet]. 2008 [cited 2020 Dec 2]. Available from: https:// www.fda.gov/regulatory-information/search-fda- guidance-documents/medical-glove-guidance- manual

US Food and Drug Administration. CFR - Code of Federal Regulations Title 21 [Internet]. 2020. [cited 2020 Dec 2]. Available from: https://www.accessdata.fda.gov/scripts/ cdrh/cfdocs/cfcfr/cfrsearch.cfm

U.S. Centers for Disease Control and Prevention. hand sanitizer use out & about [Internet]. 2020[cited 2020 Dec 2]. Available from: https://www.cdc.gov/handwashing/hand- sanitizer-use.html

World Health Organization. Technical Specifications of Personal Protective Equipment for COVID-19 [Internet]. 2020 [cited 2021 Jan 8]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-PPE_specifications-2020.1

Mylon P, Lewis R, Carré MJ, Martin N. A critical review of glove and hand research with regard to medical glove design. Ergonomics. 2014;57(1):116-129.

Agrawal AA, Konno K. Latex: a model for understanding mechanisms, ecology, and evolution of plant defense against herbivory. Annu Rev Ecol Evol Syst. 2009;40:311-331.

Yip E, Cacioli P. The manufacture of gloves from natural rubber latex. J Allergy Clin Immunol. 2002;110(2):3-14.

Rego A, Roley L. In-use barrier integrity of gloves: latex and nitrile superior to vinyl. Am J Infect Control. 1990;27(5):405-410.

Murray C, Burke, McHugh S. An assessment of the incidence of punctures in latex ann non-latex dental examination gloves in routine clinical practice. Br Dent J. 2001;190(7): 377-380.