Cell Cytotoxicity Evaluation of Silver Microemulsion for Intranasal Antibacterial Use in Acute Bacterial Rhinosinusitis: A Pharmacological Study

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Published: Nov 7, 2023
Keywords:
Cell Cytotoxicity Silver Microemulsion Acute Bacterial Rhinosinusitis

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Prayuth Poowaruttanawiwit
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand
Kwanchai Rattanamanee
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand
Niratcha Chaisomboon
Graduated Student, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand
Hathairat Lekatana
Department of Restorative dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, 65000, Thailand
Chanida Chantim
Department of Otolaryngology, Faculty of Medicine, Naresuan University, Phitsanulok, 65000, Thailand

Abstract

Acute bacterial rhinosinusitis is a commonly observed condition marked by inflammation and infection of the sinuses, prompting the exploration of alternative therapeutic approaches, such as the utilization of topical antibacterial agents incorporating silver nanoparticles. However, prior to clinical translation, a comprehensive evaluation of the safety profile is indispensable. This review article places emphasis on diverse safety pharmacological investigations, specifically cell cytotoxicity assays, conducted to assess the potential adverse effects of silver microemulsion on human cells. Additionally, this review highlights other pharmacological methodologies aimed at ensuring safety prior to efficacy testing and subsequent formulation development of an appropriate preparation.

Article Details

Issue
Vol. 3 No. 2 (2023): July-December
Section
Review Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Upon acceptance of an article, the Pharmacological and Therapeutic Society of Thailand will have exclusive right to publish and distribute the article in all forms and media and grant rights to others. Authors have rights to use and share their own published articles.

Author Biography

Niratcha Chaisomboon, Graduated Student, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand

graduate student

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