Cell Cytotoxicity Evaluation of Silver Microemulsion for Intranasal Antibacterial Use in Acute Bacterial Rhinosinusitis: A Pharmacological Study

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Prayuth Poowaruttanawiwit
Kwanchai Rattanamanee
Niratcha Chaisomboon
Hathairat Lekatana
Chanida Chantim


Acute bacterial rhinosinusitis is a commonly observed condition marked by inflammation and infection of the sinuses, prompting the exploration of alternative therapeutic approaches, such as the utilization of topical antibacterial agents incorporating silver nanoparticles. However, prior to clinical translation, a comprehensive evaluation of the safety profile is indispensable. This review article places emphasis on diverse safety pharmacological investigations, specifically cell cytotoxicity assays, conducted to assess the potential adverse effects of silver microemulsion on human cells. Additionally, this review highlights other pharmacological methodologies aimed at ensuring safety prior to efficacy testing and subsequent formulation development of an appropriate preparation.


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Review Articles
Author Biography

Niratcha Chaisomboon, Graduated Student, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand

graduate student


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