Main Article Content
Acute bacterial rhinosinusitis is a commonly observed condition marked by inflammation and infection of the sinuses, prompting the exploration of alternative therapeutic approaches, such as the utilization of topical antibacterial agents incorporating silver nanoparticles. However, prior to clinical translation, a comprehensive evaluation of the safety profile is indispensable. This review article places emphasis on diverse safety pharmacological investigations, specifically cell cytotoxicity assays, conducted to assess the potential adverse effects of silver microemulsion on human cells. Additionally, this review highlights other pharmacological methodologies aimed at ensuring safety prior to efficacy testing and subsequent formulation development of an appropriate preparation.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Upon acceptance of an article, the Pharmacological and Therapeutic Society of Thailand will have exclusive right to publish and distribute the article in all forms and media and grant rights to others. Authors have rights to use and share their own published articles.
Patel ZM, Hwang PH. Acute bacterial rhinosinusitis. Infections of the Ears, Nose, Throat, and Sinuses. 2018;4:133–143.
DeBoer DL, Kwon E. Acute sinusitis. In: StatPearls [Internet]. 2023 [cited 2023 Mar 29]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547701/
Autio TJ, Tapiainen T, Koskenkorva T, Närkiö M, Lappalainen M, Nikkari S, et al. The role of microbes in the pathogenesis of acute rhinosinusitis in young adults. Laryngoscope. 2015;125:E1-7.
Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein EJ, Hicks LA, et al.IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012;54:e72-e112.
Wald ER, Applegate KE, Bordley C, Darrow DH, Glode MP, Marcy Smet al.Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pediatrics. 2013;132:e262-e280.
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI. Antibiotics for acute rhinosinusitis in adults. Cochrane Database Syst Rev. 2018;9:CD006089.
Jiam NT, Goldberg AN, Murr AH, Pletcher SD. Surgical treatment of chronic rhinosinusitis after sinus lift. Am J Rhinol Allergy. 2017;31:271-275.
Cho SH, Ledford D, Lockey RF. Medical management strategies in acute and chronic rhinosinusitis. J Allergy Clin Immunol Pract. 2020;8(5):1559-1564.
Williamson IG, Rumsby K, Benge S, Moore M, Smith PW, Cross M, et al. Antibiotics and topical nasal steroid for treatment of acute maxillary sinusitis: a randomized controlled trial. JAMA. 2007;298(21):2487-2496.
El-Hennawi DM, Ahmed MR, Farid AM, Al Murtadah AM. Comparative study of the efficacy of topical steroid and antibiotic combination therapy versus oral antibiotic alone when treating acute rhinosinusitis. J Laryngol Otol. 2015;129(5):462-467.
Woodhouse BM, Cleveland KW. Nebulized antibiotics for the treatment of refractory bacterial chronic rhinosinusitis. Ann Pharmacother. 2011;45(6):798-802.
Jervis-Bardy J, Boase S, Psaltis A, Foreman A, Wormald PJ. A randomized trial of mupirocin sinonasal rinses versus saline in surgically recalcitrant staphylococcal chronic rhinosinusitis. Laryngoscope. 2012;122(10):2148-2153.
Sim W, Barnard RT, Blaskovich MAT, Ziora ZM. Antimicrobial silver in medicinal and consumer applications: A patent review of the past decade (2007⁻2017). Antibiotics (Basel). 2018;7:93.
Mijnendonckx K, Leys N, Mahillon J, Silver S, Van Houdt R. Antimicrobial silver: uses, toxicity and potential for resistance. Biometals. 2013;26:609-621.
Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH. The antibacterial mechanism of silver nanoparticles and its application in dentistry. Int J Nanomedicine. 2020;15:2555-2562.
Mohamed DS, Abd El-Baky RM, Sandle T, Mandour SA, Ahmed EF. Antimicrobial activity of silver-treated bacteria against other multi-drug resistant pathogens in their environment. Antibiotics (Basel). 2020;9:181.
Zhang XF, Shen W, Gurunathan S. Silver nanoparticle-mediated cellular responses in various cell lines: An in vitro model. Int J Mol Sci. 2016;17:1603.
Mello DF, Trevisan R, Rivera N, Geitner NK, Di Giulio RT, Wiesner MR, et al. Caveats to the use of MTT, neutral red, Hoechst and Resazurin to measure silver nanoparticle cytotoxicity.Chem Biol Interact. 2020;315:108868.
Haase A, Dommershausen N, Schulz M, Landsiedel R, Reichardt P, Krause BC, et al. Genotoxicity testing of different surface-functionalized SiO2, ZrO2 and silver nanomaterials in 3D human bronchial models. Arch Toxicol. 2017;91:3991-4007.
López-Serrano Oliver A, Haase A, Peddinghaus A, Wittke D, Jakubowski N, Luch A, et al. Mass cytometry enabling absolute and fast quantification of silver nanoparticle uptake at the single cell level. Anal Chem.2019;91:11514-11519.
Kawakami K, Yoshikawa T, Moroto Y, Kanaoka E, Takahashi K, Nishihara Y, et al. Microemulsion formulation for enhanced absorption of poorly soluble drugs. I. Prescription design. J Control Release. 2002;81:65-74.
Zhang XF, Liu ZG, Shen W, Gurunathan S. Silver nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci. 2016;17:1534.
Pareek V, Gupta R, Panwar J. Do physico-chemical properties of silver nanoparticles decide their interaction with biological media and bactericidal action? A review. Mater Sci Eng C Mater Biol Appl. 2018;90:739-749.
Riaz Ahmed KB, Nagy AM, Brown RP, Zhang Q, Malghan SG, Goering PL. Silver nanoparticles: Significance of physicochemical properties and assay interference on the interpretation of in vitro cytotoxicity studies. Toxicol In Vitro. 2017;38:179-192.
Danai L, Rolband LA, Perdomo VA, Skelly E, Kim T, Afonin KA. Optical, structural and antibacterial properties of silver nanoparticles and DNA-templated silver nanoclusters. Nanomedicine (Lond). 2023;18:769-782.
Akter M, Sikder MT, Rahman MM, Ullah AKMA, Hossain KFB, Banik S, et al. A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives. J Adv Res. 2017;9:1-16.