Antiplatelet and Antioxidative Effects of Stephania venosa (Blume) Spreng. Extract

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Kwanchai Rattanamanee


The purpose of this investigation was to determine the antiplatelet aggregation and antioxidative effects of methanolic extract from Stephania venosa (Blume) Spreng. This tested extract was studied for inhibitory activity on platelet aggregation-induced by adenosine diphosphate (ADP) in human platelet-rich plasma (PRP) and antioxidative effect by DPPH radical scavenging and ferric reducing antioxidant power (FRAP) assays. The platelet aggregation test was performed by using light transmission method. The results showed that methanolic extract from Stephania venosa (Blume) Spreng. possesses inhibitory activity on platelet aggregation with IC50 of 55.9 µg/ml. The extract exhibited antioxidant activity with the IC50 of 164.77µg/ml by DPPH radical scavenging assay. FRAP assays also revealed that the extract possesses antioxidant potentials. Stephania venosa (Blume) Spreng. could be a source of novel antiplatelet and antioxidant compounds for the management of various hematological disorders.


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