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In this study, we assessed the effects of RVV on renal hemodynamics, urinary enzymes, plasma and urinary Tx in 7 dogs during and after a 40-min intrarenal arterial infusion of RVV (1.25 μg/kg/min). All parameters were determined before and at 20, 40 and 60 min after the beginning of RVV. The urinary enzymes measured included N-acetyl-ß-D-glucosaminidase (NAG). γ-glutamyl, transpeptidase (γ-GT), alanine-aminopeptidase(AAP) and ß-galactosidase (GAL). Plasma and urinary Tx were measured by radioimmunoassay after extraction and purification steps.
As compared with the control stage, significant change was observed for a decrease in the mean arterial pressure (MAP) during the first 20 min after RVV administration (128.4 ± 7.7 vs. 118 ± 10.2 mm Hg. mean±SE, p < 0 .025) as well as the fractional excretion of sodium (), potassium ( ), and chloride () (p <0.05). The heart rate (HR), renal blood flow (RBF) and glomerular tiltration rate (GFR) did·not change significantly for all period of observation. Urine flow (V) increased by approximately 15.4-65.4% in 5 dogs and decreased 6.6-32.9% in 2 dogs. increased significantly 40 min after the commencement of RVV infusion (727 ±301 VS. 1484 ± 386 units/min, p < 0.005). A 7-to 9-fold elevation of was detected for all periods of observation but was significantly increased during the first 20 min after RVV infusion
This study showed : (1) The changes of RBF and GFR could not explain the rise of V, excretion of electrolytes and . They should rather be accounted for by direct tubular dysfunction (2) Plasma increased in parallel with suggesting an augmented synthesis of and/or disturbance of active reabsorption of by tubular cells.(3) The elevation of NAG indicated direct nephrotoxicity of RVV.
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