Main Article Content
Pretreatment of the rats with methotrexate, cyclophosphamide and 5-fluorouracil could cause inhibition of hepatic drug metabolism of zoxazolamine, aminopyrine and aniline, as evidenced by a prolongation of zoxazolamine paralysis time and a decrease in the elimination of the latter two amines from the plasma. However, the rate of absorption of both aminopyrine and aniline were unaffected. In vitro investigations were consistent with the view that the most likely cause of this inhibited hepatic drug metabolism produced by these anticancer agents was the reduction in one or more components of the drug-metabolizing enzyme system, including the cytochrome P450 content.
Upon acceptance of an article, the Pharmacological and Therapeutic Society of Thailand will have exclusive right to publish and distribute the article in all forms and media and grant rights to others. Authors have rights to use and share their own published articles.