A Comparative Study on The Bioa V Ailability of Acyclovir Tablets in Thai Volunteer

Abstract

The bioavailabilityof the two local made and one imported products of acyclovirtablet obtained commercially was evaluated in ten Thai subjects (five males and five females) with the past history of infection by herpes simplex virus. A single oral dose of each acyclovir product (200 milligrams x 4 tablets) was taken by all subjects.The study was performed by using a complete cross-over design experiment with one week wash out period. Blood samples were taken at 0, 20, 40 minutes, 1, 1.5, 2, 3, 5, 7 and 9 hours after drug administration. The plasma drug concentrations were determined using high pressure liquid chromatography technique (HPLC). The timeof peak plasma concentration (T_max)· the peak plasma concentration (C_{p max}) and area under the plasma concentration-time curve (AUC _0-∞) were not statistically differentfrom each other and between sex (P>0.05). However, only the absorption rateconstant (Ka) of one locally made acyclovir tablets was statistically different from theoriginal product (P<0.05).