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Leaves of Sa-Gae-Krur (Combretum decandrum Roxb.) have been used as an
traditional medicine for diabetes mellitus, especially in Northeast of Thailand.
However, there is no experimental evidence of its hypoglycemic effect. Therefore,
this study has an objective to evaluate the antidiabetic activity of the extract of Sa-Gae-Krur
both in normal and diabetic rats. 50% ethanolic extract of dried Sa-Gae-Krur
leaves was used in all experiments. Adult male rats (250-330 g) were made
diabetic by injection of streptozotocin intraperitoneally at dose of 45 mg/kg. One
week after streptozotocin injection, the fasting blood glucose was determined by
glucose oxidase test. Rats with fasting blood glucose above 180 mg/100ml were
considered as diabetic and included in the experiment. The diabetic rats were
randomly given either distilled water, various doses of extract or insulin for 3
consecutive days. The orally administration of Sa-Gae-Krur at doses of 0.5, 0.75 and
1 g/kg/d significantly (P<0.05) decreased the glucose plasma level by 43.6±8.43
(n=4), 58.78±12.72 (n=5) and 37.0±5.45 (n=6) % respectively. In the insulin treated
group (Mixtard HM®, 4U/kg/d), the plasma glucose were drastically decreased by
87.67±2.15 (n=6) %. Interestingly, the extract of Sa-Gae-Krur at doses of 1 g/kg/d
had no hypoglycemic effect on normal rats. These results suggest that the Sa-Gae-Krur
leave extract possesses antidiabetic effects in streptozotocin-induced diabetic rats.
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