Utilization of Restricted Antibiotics in a University Hospital in Thailand
Main Article Content
Abstract
Antibiotic resistance, a major negative consequence of antibiotic overuse, is
one of the mainstay problems worldwide. Various means have been used to control
antibiotic usage including the use of an antibiotic order form (AOF), restricted
antibiotic formularies and provision of educational information. The present study
was designed to evaluate the use of antimicrobial in a 1,000-bed university hospital.
Antimicrobial agents which are likely to be abused namely ceftazidime, cefepime,
cefoperazone/sulbactam, imipenem/cilastatin, meropenem, ciprofloxacin, netilmicin,
vancomycin, azithromycin and clarithromycin were selected for evaluation. A simple
AOF with educational information was used as a mean to follow-up the treatment.
The investigator collected data from the filled AOF and the patient's charts,
Department of Internal Medicine from June - November 2000, and all relevant data
were assessed. The appropriateness of antibiotic use was assessed according to the
criteria specified in the AOF showed that 74% of these antibiotics were prescribed
appropriately. This may prove the effectiveness of the system used in the present
study. However, 348 of the 430 prescriptions (80.9%) were prescribed empirically at
the initial stage for treatment of nosocomial infections in patients with serious
conditions like pneumonia, sepsis and febrile neutropenia. Drugs that were frequently
used empirically were ceftazidime (37.9%), imipenem/cilastatin or meropenem
(19 .3% ), and cefoperazone/sulbactam ( 12.1 % ) respectively. Ceftazidime and
imipenem/cilastatin or meropenem were also frequently used inappropriately among
111 prescriptions that were classified as an inappropriate prescribing. The most
common misuses were prescriptions of the drug that did not follow the specified
indications (70 prescriptions), no dosage adjustment in patients with renal impairment
(39 prescriptions), improper dose (12 prescriptions) and improper dosing interval (9
prescriptions). The results suggested overuse of certain antibiotics remain to be an
unsolved problem. A better monitoring and strictly control the use of the problematic
antibiotics, i.e. ceftazidime, imipenem/cilastatin or meropenem and vancomycin are
essential to promote the rational drug use as well as to reduce drug resistance.
Article Details
Upon acceptance of an article, the Pharmacological and Therapeutic Society of Thailand will have exclusive right to publish and distribute the article in all forms and media and grant rights to others. Authors have rights to use and share their own published articles.