Neurotonic Thai Plants Reduce Reactive Oxygen Species Production in SHSY5Y Neuroblastoma Cells

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Nanteetip Limpeanchob
Anussara Inneam
Kornkanok Ingkaninan


Oxidative stress is considered an important causative factor in several
neurodegenerative diseases. This study was aimed to determine the antioxidant properties of
seven neurotonic Thai plants with possible neuroprotective effect in humans. Antioxidant
power was evaluated by ferric reduction, lipid peroxidation inhibition and intracellular
reactive oxygen species (ROS) suppression. The results showed that the extracts from
Terminalia bellirica (Gaertn.) Roxb. and Albizia procera (Roxb.) Benth. could act as ferric
reducing agents, whereas those of Cassia fistula L. and Stephania suberosa Forman seemed
to be potent inhibitors of lipid peroxidation. These plant extracts could also effectively
suppress the formation of intracellular ROS in differentiated SH-SY5Y neuroblastoma cells.
In the conclusion, most of the selected plants demonstrated strong antioxidant activity by
acting as metal reducing agents, lipid peroxidation inhibitors, and/or intracellular ROS
suppressants. This study provides the potential mechanisms of Thai neurotonic plants as
neuroprotective agents which could be beneficial in the prevention or delay of
neurodegenerative processes.


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2010 Annual Meeting Abstracts/Lectures