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The purpose of this study was to investigate the influence of a standardized extract
from Centella asiatica (ECa-233) and asiaticoside (ATS) on vinblastine (VBL)-induced
cytotoxicity in porcine renal epithelial cell line (LLC-PK1) and its MDR1-gene-transfected
epithelial cell line (LLC-MDR1). The cells were co-treated with VBL (at various
concentrations) and either ECa-233 or ATS for 72 hr prior to determination of cell viability
with the MTT assay. Our results showed that the noncytotoxic ECa-233 and ATS could
enhance the cytotoxicity of VBL in both cell types. It was likely that both ECa-233 and ATS
were able to inhibit the function of P-glycoprotein, a known membrane efflux pump of VBL
and might be useful in cancer chemotherapy.
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