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We investigated anti-tumor activity of the dichloromethane extract from branches of
Micromelum hirsutum on human B lymphoma cells, Ramos. The extract exhibited Ramos
cell cytotoxicity in a concentration-dependent manner with IC50 41.88 μg/ml at 24 h
exposure. It induced cell death mainly by apoptosis at 12 h exposure. This apoptotic
induction activity of the extract was markedly mediated by caspase activation. The extract
induced Ramos cell accumulation at S and G2/M phase of the cell cycle. Our result
demonstrated that the dichloromethane extract from branches of M. hirsutum has anti-tumor
potential against B lymphoma.
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