Effects of Xanthoxylin on Melanogenesis

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Keywords:
xanthoxylin melanogenesis melanin tyrosinase

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Wannapa Moleephan
Inter-department Program of Pharmacology, Graduate School, Chulalongkorn University.
Supeecha Wittayalertpanya
Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330
Nijsiri Ruangrungsi
3Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330
Wacharee Limpanasithikul
Department of Pharmacology, Faculty of Medicine, Chulalongkorn University.

Abstract

The important role of melanin is skin protection against UV radiation from sunlight

which induces DNA damage and skin cancer. The purposes of this study were to determine

the effects of xanthoxylin on melanin content by measure melanin content at 405 nm, mRNA

expression of regulatory melanogenesis proteins by RT-PCR and dendriticity in mouse

B16F10 melanoma cells by photograph the pictures under microscope. This study found that

xanthoxylin increased melanin content and mRNA expression of regulatory melanogenesis

proteins (tyrosinase and Mitf). In addition, xanthoxylin also increased dendrites of mouse

B16F10 melanoma cells and no effect on viability of mouse B16F10 melanoma cells. It could

be concluded that xanthoxylin induced melanogenesis, increased dendrites and activated

tyrosinase and Mitf expressions in mouse B16F10 melanoma cells.

Article Details

Issue
Vol. 32 No. 1 (2010): Thai Journal of Pharmacology
Section
2010 Annual Meeting Abstracts/Lectures

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