Main Article Content
The important role of melanin is skin protection against UV radiation from sunlight
which induces DNA damage and skin cancer. The purposes of this study were to determine
the effects of xanthoxylin on melanin content by measure melanin content at 405 nm, mRNA
expression of regulatory melanogenesis proteins by RT-PCR and dendriticity in mouse
B16F10 melanoma cells by photograph the pictures under microscope. This study found that
xanthoxylin increased melanin content and mRNA expression of regulatory melanogenesis
proteins (tyrosinase and Mitf). In addition, xanthoxylin also increased dendrites of mouse
B16F10 melanoma cells and no effect on viability of mouse B16F10 melanoma cells. It could
be concluded that xanthoxylin induced melanogenesis, increased dendrites and activated
tyrosinase and Mitf expressions in mouse B16F10 melanoma cells.
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