Protective Effects of Curcumin Against Dopamine Quinone-induced Dopaminergic Neurotoxicity in SH-SY5Y Cells

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Benjawan Meesarapee
Yamaratee Jaisin
Anusorn Thampithak
Apichart Suksamrarn
Laddawal Phivthong-ngam
Noppawan Phumala Morales
Yupin Sanvarinda


Auto-oxidation of 6-hydroxy dopamine (6-OHDA) has been known to generate free
radicals and subsequent quinone proteins formation which is toxic to dopaminergic neurons.
Curcumin, is a pure compound extracted from Curcuma longa which known to possess antioxidant,
anti-inflammatory and anti-carcinogenic activities. In this study, we investigated the
effects of curcumin on 6-OHDA-induced neurotoxicity in SH-SY5Y cells. It was found that
curcumin significantly increased the viability of the cells. Along with the increase in cell
survival the quinoprotein production was significantly decreased. These results indicate that
curcumin has neuroprotective effects and may have a therapeutic potential for treatment of
Parkinson disease.


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2010 Annual Meeting Abstracts/Lectures