Protective Effects of Curcumin Against Dopamine Quinone-induced Dopaminergic Neurotoxicity in SH-SY5Y Cells

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Keywords:
6-OHDA quinoprotein Curcuma longa

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Benjawan Meesarapee
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400
Yamaratee Jaisin
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400
Anusorn Thampithak
Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131
Apichart Suksamrarn
Department of Chemistry, Faculty of Science, Ramkamheang University, Bangkok
Laddawal Phivthong-ngam
Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok
Noppawan Phumala Morales
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400
Yupin Sanvarinda
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400

Abstract

Auto-oxidation of 6-hydroxy dopamine (6-OHDA) has been known to generate free
radicals and subsequent quinone proteins formation which is toxic to dopaminergic neurons.
Curcumin, is a pure compound extracted from Curcuma longa which known to possess antioxidant,
anti-inflammatory and anti-carcinogenic activities. In this study, we investigated the
effects of curcumin on 6-OHDA-induced neurotoxicity in SH-SY5Y cells. It was found that
curcumin significantly increased the viability of the cells. Along with the increase in cell
survival the quinoprotein production was significantly decreased. These results indicate that
curcumin has neuroprotective effects and may have a therapeutic potential for treatment of
Parkinson disease.

Article Details

Issue
Vol. 32 No. 1 (2010): Thai Journal of Pharmacology
Section
2010 Annual Meeting Abstracts/Lectures

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