Evaluation of Antinociceptive Activity of the Ethanolic Extract from Scaphium lychnophorum (Hance) Pierre Fruit in Mice
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Abstract
The antinociceptive activity of the ethanolic extract from the fruit of Scaphium
lychnophorum was assessed in mice using in vivo animal models included the acetic acidinduced
writhings, formalin, and hot plate tests. The acute toxicity of the ethanolic extract
was also performed in mice. The results demonstrated that the ethanolic extract from the fruit
of Scaphium lychnophorum markedly showed the antinociceptive activity at doses of 50, 100
and 200 mg/kg, po when compared with the control (p < 0.05). The estimated LD50 in mice
was more than 5 g/kg.
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