Effects of Curcuminoid on Ethanol-induced Toxicity in Hepatic Cells and Rats

Abstract

Alcoholic liver disease (ALD) is caused by excessive consumption of alcohol. The
pathological progress of ALD involves in increasing reactive oxygen species (ROS) and
nitric oxide (NO) production, cytokines secretions, and inflammatory reactions.
Curcuminoid, a mixture of active substance derived from turmeric compound, has exhibited
an antioxidant and anti-inflammatory properties. This study aimed to examine effect of
curcuminoid on NO production in ethanol-stimulated hepatic cells and on hepatoprotective
effect in ethanol-induced toxicity rats. We found that curcuminoid at lower concentration
(0.313 and 0.625 μg/ml) tended to reduce NO production in the ethanol-stimulated cells. In
addition, curcuminoid at concentration 500 and 750 μg/ml decreased the liver function
enzymes significantly in the ethanol-induced toxicity rats. The results suggested that
curcuminoid had a potential property to be use as a hepatoprotective agent in ethanol-induced
hepatic toxicity.