Effects of Phyllantus Amarus Aqueous Extract and Phyllanthus Emblica Aqueous Extract on Human CYP2D6 and CYP3A4

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Napaporn Anannarukan
Nuansri Niwattisaiwong
Warangkana Warisnoicharoen
Pornpen Pramyothin
Somsong Lawanprasert


Phyllanthus amarus Schum. & Thonn. and Phyllanthus emblica Linn. are well-known
as herbal medicine with many pharmacological effects. Inhibitory effects of the aqueous
extracts of both plants on cytochrome P450 (CYP) including CYP2D6 and CYP3A4, were
investigated using recombinant human CYP. The results demonstrated that P. amarus
aqueous extract and P. emblica aqueous extract possessed inhibitory effects on CYP2D6 with
IC50 of 180.02 μg/mL and 599.34 μg/mL, respectively. Inhibitory effects of P. amarus
aqueous extract and P. emblica aqueous extract on CYP3A4 were shown by the IC50 of 2.11
μg/mL and 321.89 μg/mL, respectively. Results from this study provide an information
indicating the possibilities of herb-drug interaction if these extracts are co-administered with
the prescribing drugs that are metabolizing by CYP2D6 and CYP3A4.


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2010 Annual Meeting Abstracts/Lectures