Selective Inhibition of Human Cytochrome P450 1A2 by Moringa oleifera
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Abstract
The use of Moringa oleifera Lam as a healthcare product in Thailand becomes very
popular during a past few years. Since medicinal plants constituents may interact with drug
metabolizing enzymes, particular cytochromes P450 (CYP) raises the potential of herb-drug
interactions. The aim of the present study was to determine the inhibitory effects of M.
oleifera extractions on human CYP activities including CYP1A2, CYP2D6, CYP2E1 and
CYP3A4 using selective substrate of these enzymes. The results revealed that both ethanolic
and aqueous extracts of M. oleifera inhibited CYP1A2, CYP2D6, CYP2E1 and CYP3A4
activities in a dose-dependent manner. Moreover ethanolic extract of M. oleifera exhibited
selective inhibition of CYP1A2 with IC50 values of 13.8 + 9.8 μg/mL incubation. The results
obtained from the present study suggested the possibility of potential herb and drug
interactions of M. oleifera. Therefore, healthcare professionals and patients should be aware
when using this medicinal plant with some prescribed drugs especially drugs that metabolized
by CYP1A2.
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