Pharmacokinetics without Equations : Factors Modifying Drug Effects in Individuals

Abstract

The majority of people respond to most drugs in a similar enough fashion to permit the calculation of a standard therapeutic dose of a drug. This statistically derived "average" dose, however, only represents the starting point from which to estimate the dose appropriate for a given subject. The many variables contributinf to the individuality of a complex living organism, or associated with the conditions present at the time of drug administration must be considered as potentially capable of modifying the anticipated drug effect.