Dual Action of Hydralazine on Rat Heart in Vivo
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Abstract
SUMMARY
1. Hydralazine 2, 4, 6, 12, 16, mg/kg IV produced a dose-dependent bradycardic and tachycardic effects on the heart rate of anaesthetized and pithed rats in situ.
2. The change in the rate of beating of isolated rat atria produced by high dose of hydralazine (2.0 mM) was enhanced by either theophylline or ICI 63 191.
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