Prevention of Tachycardic Action of Hydralazine

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Prasert Songkittiguna
Giatibungon Jindagul



The hypotensive action of hydralazine (0.5-2 mg/kg) was enhanced by pretreatment of normotensive anesthetized rats with the drugs: haloperidol (0.21 mg/kg), indomethacin (3 mg/kg) and atropine (0.5 mg/kg) The corresponding tachycardia produced by hydralazine was abolished by haloperido/ or indomethacin or atropine. The hypotensive potentiation of the drugs with hydralazine is worth studying.


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