Antioxidant Vitamins and Lipid Peroxidation Abnormalities in Thai Patients with Chronic Renal Failure

Abstract

Oxidative stress has been shown from other publications to play an importance role in pathogenesis of renal disease and the progress of the disease up to end stage. The present study was pe1formed in 54 Thai chronic renal failure (CRF) patients with oxidative stress status and was compared to 32 normal subjects. The results revealed that CRF patients were deficient in red blood cell α-tocopherol(vitamin E). These patients had higher rates of lipid peroxidation and were highly susceptible to red cell hemolysis. The results thus confirmed the existence of impaired antioxidant system. Our study also suggested that oral supplementation of α-tocopherol in chronic renal failure patients should be further study.