Main Article Content
The present study was undertaken to evaluate roselle (Hibiscus sabdarifla) for its anti-ulcer activity. Roselle mucilage fraction (RMF) was isolated and examined in experimentally ulcerated rats. Oral administration of the RMF from 125-500 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, ethanol and water immersion restraint stress. Anti-gastric secretory effect of the RMF in pylorus-ligated rats was not clearly demonstrated since the gastric volume, pH and acidity output were not affected by the RMF pretreatment in a dose-related manner. In acidified ethanol induced ulcerated rats, gastric wall mucus but not hexosamine content, was markedly preserved by the RMF pretreatment. The findings indicate that roselle mucilage possesses gastroprotective potential which is related to a cytoprotective mechanism via preservation of gastric mucus content.
Upon acceptance of an article, the Pharmacological and Therapeutic Society of Thailand will have exclusive right to publish and distribute the article in all forms and media and grant rights to others. Authors have rights to use and share their own published articles.