Gastroprotective Effect of Roselle Mucilage

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Chaiyong Rujjanawate
Laboratory of Natural Products, Chulabhorn Research Institute, Research Center at Chiangmai University, Faculty of Medicine, Chiangmai University, Chiangmai 50200
Duangporn Amornlerdpison
Laboratory of Natural Products, Chulabhorn Research Institute, Research Center at Chiangmai University, Faculty of Medicine, Chiangmai University, Chiangmai 50200
Duangta Kanjanapothi
Laboratory of Natural Products, Chulabhorn Research Institute, Research Center at Chiangmai University, Faculty of Medicine, Chiangmai University, Chiangmai 50200

Abstract

The present study was undertaken to evaluate roselle (Hibiscus sabdarifla) for its anti-ulcer activity. Roselle mucilage fraction (RMF) was isolated and examined in experimentally ulcerated rats. Oral administration of the RMF from 125-500 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, ethanol and water immersion restraint stress. Anti-gastric secretory effect of the RMF in pylorus-ligated rats was not clearly demonstrated since the gastric volume, pH and acidity output were not affected by the RMF pretreatment in a dose-related manner. In acidified ethanol induced ulcerated rats, gastric wall mucus but not hexosamine content, was markedly preserved by the RMF pretreatment. The findings indicate that roselle mucilage possesses gastroprotective potential which is related to a cytoprotective mechanism via preservation of gastric mucus content.

Article Details

Issue
Vol. 23 No. 2-3 (2001)
Section
Research Articles

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