Inhibitory Effect of Methanol and Hexane Extracts of Moringa oleifera Lam Leaves on NO Production in LPS-activated Microglia

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Busarat Karachot
Anusorn Thampithak
Nattinee Jantaratnotai
Yamaratee Jaisin
Benjawan Meesarapee
Patoomratana Tuchinda
Yupin Sanvarinda


Moringa oleifera Lam(M.oleifera), is generally found in tropical areas, South Asia
and Thailand. It has been used for the treatment of various diseases including inflammation.
However, little is known about its anti-inflammatory activity. We, therefore studied the effect
of crude extracts from leaves (Methanol and hexane fractions) of M. oleifera on the
production of nitric oxide (NO), a pro-inflammatory substance in highly aggressively
proliferating immortalized (HAPI) microglial cells activated by lipopolysaccharide(LPS) and
found that the extracts from M. oleifera significantly suppressed nitric oxide production in a
dose dependent manner. This preliminary result demonstrates that the anti-inflammatory
activity of the crude extracts of M. oleifera leaves is due partly through the inhibition of NO
production and suggests that M. oleifera may have neuroprotective potential in
neurodegenerative diseases caused by neuroinflammation.


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2010 Annual Meeting Abstracts/Lectures