The Pharmacological Effect of Quercetin Isolated from the leaves of Psidium Guajava (Myrtaceae) on Isolated Rat and Guinea-pig Ileum Preparation

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Amphawan Apisariyakul
Nuchanart Chaichana
Wilasinee Yousukh


Quercelin, 3,3,4,5, 7-pentahydroxyflavone, a compound of yellow powder extracted from natural sources such as the leaves of Psidium guajava (Myrtaceae) exerted an inhibition of the smooth muscle contraction induced by acetylcholinem, serotonin, histamine and barium chloride on isolated guinea-pig ileum preparation. It was shown that quercetin could inhibit ileum contraction induced by spasmogens with different pharmacological mechanisms and produced the inhibition of acetylcholine much more than that of serotonin, histamine and barium chloride. Therefore, the results suggested that quercetin exerts its anticholinergic properties on isolated smooth muscle preparation


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