Interaction of Pentobarbital and Neuromuscular Blocking Drugs

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Amphawan Apisariyakul
Nuanchan Chanmahasatien


The effect of pentobarbital sodium was studied in both rat phrenic nerve-hemidiaphragm and rat sciatic nerve-gastrocnemius preparations. It was found that pentobarbital produced twitch depression leading to a complete neuromuscular blockade. The pentobarbital-induced neuromuscular depression was significantly enhanced by d-tubocurarine, succinylcholine and hemicholinium. In chronically denervated muscle, pentobarbital also suppressed acetylcholine (ACh)-contracture. The mechanism of neuromuscular blockade produced by pentobarbital may be (a) reduction of ACh release from motor nerve ending or (b) decrease sensitivity of motor end-plate to Ach.


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