An Intercellular Messenger: Nitric Oxide
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Abstract
Nitric oxide (NO), a potentially toxic molecule, plays a role as an important second messenger. It has been implicated in a wide range of biological functions, such as blood pressure regulation, blood clotting, and neurotransmission. The regulation, signal transduction and cytotoxicity of NO is strictly dependent upon its chemical reactivity with oxygen and metals rather than specific structural interactions with physiological targets. The properties, biosynthesis, physiological roles, involvement in pathophysiology and therapeutic potential of NO are reviewed.
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