Guava, Papaya, Pineapple, and Pomelo Juices Inhibit Pancreatic Lipase Activity and Cholesterol Micelle Solubility

Abstract

High fat consumption has been identified as one of the critical factors leading to obesity and several metabolic syndromes. Because restriction of diet is difficult for most people, an alternative dietary intervention is received special attention. This study aimed to investigate the potential of fruit juices for their capacity to reduce lipid digestion through the inhibitory activities against pancreatic lipase and micellar cholesterol solubility. Guava, papaya, pineapple and pomelo were selected for the study. Both effects were determined using freshly prepared and freeze-dried preparations of fruit juices. The result showed that fruit juices dose-dependently inhibited pancreatic lipase activity and solubility of cholesterol in lipid micelles. Among four species, papaya exhibited the highest pancreatic lipase inhibitory activity whereas guava showed the highest inhibition on micellar cholesterol solubility.  Freshly prepared and freeze-dried juices were not statistically different by these two investigations. The results suggest that fruit juices consumption may potentially inhibit intestinal lipid digestion and consequently being helpful for weight and serum lipid controls.