Roles of Inflammation in Neurodegenerative Diseases

Main Article Content

Kanathip Singsai
Jintana Sattayasai


Inflammation is a biological response to injury. Although inflammatory processes have many benefits and are related to tissue repairing processes, out of control of the inflammatory response might facilitate the production of neurotoxic factors and cause many chronic diseases including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s diseases, amyotrophic lateral sclerosis, and multiple sclerosis. Actually, neurodegenerative diseases are induced by specific-disease mechanisms, with different sites of injury and specific pathophysiologic responses to inflammatory processes. Interestingly, these diseases have been involved with inflammatory processes. Triggering process with inducers, sensors, transducers, and effectors can induce the amplification of inflammatory responses leading to neurotoxicity and neuronal death. Therefore, inhibition of the inflammatory responses might reduce the progression of the diseases. Reviewing the role of anti-inflammatory agents in nervous system might be benefit for preventing or treating neurodegenerative diseases.


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Article Details

Review Articles
Author Biographies

Kanathip Singsai, University of Phayao

Department of Pharmaceutical care, School of Pharmaceutical sciences

Jintana Sattayasai, Khon Kaen University

Department of Pharmacology, Faculty of Medicine


Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010;140(6):918-34.

Mrak RE, Griffin W. Glia and their cytokines in progression of neurodegen-eration. Neurobiol Aging. 2005;26:349-54.

Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22(2):240-73.

Skaper SD. The brain as a target for inflammatory processes and neuroprotective strategies. Ann N Y Acad Sci. 2007;1122:23-34.

Balistreri CR, Colonna-Romano G, Lio D, Candore G, Caruso C. TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases. J Clin Immunol. 2009;29:406-15.

Viviani B, Bartesaghi S, Corsini E, Galli CL, Marinovich M. Cytokines role in neurodegenerative events. Toxicol Lett. 2004;149:85-9.

Michelucci A, Heurtaux T, Grandbarbe L, Morga E, Heuschling P. Character-ization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta. J Neuroimmunol. 2009;210(1-2):3-12.

Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Clin Pharmacol. 2006;147:232-40.

Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation induced death. Cell. 2009;137:47-59.

Zhang JM, An J. Cytokines, inflammation and pain. Int Anesthesiol Clin. 2007;45(2):27-37.

Wilson CJ, Finch CE, Cohen HJ. Cytokines and cognition-The case for a head-to-toe inflammatory paradigm. JAGS. 2002;50:2041-56.

Yamin G. NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus. J Neurosci Res. 2009;87:1729-36.

Rissman RA, De Blas AL, Armstrong DM. GABA(A) receptors in aging and Alzheimer's disease. J Neurochem. 2007;103:1285-92.

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005;19:533-42.

Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol. 2009;8:382-97.

McGeer PL, McGeer EG. Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve. 2002;26:459-70.

Yiangou Y, Facer P, Durrenberger P, Chessell IP, Naylor A, Bountra C, et al. COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol. 2006;6:12.

Lassmann H, Bruck W, Lucchinetti C. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med. 2001; 7:115-21.

Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol. 2005;23:683-747.

Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol. 2009;9:393-407.

Perez J, Ruiz J. A review: Inflammatory process in Alzheimer’s disease, role of cytokines. Sci World J. 2012;2012:756357.

Mestre L, Correa F, Docagne F, Clemente D, Guaza C. The synthetic cannabinoid WIN 55, 212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection. Biochem Pharmacol. 2006;72(7):869-80.

Moore AH, O’Banion MK. Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease. Adv Drug Deliv Rev. 2002;54:1627-56.

Lleo A, Galea E, Sastre M. Review: Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases. Cell Mol Life Sci. 2007;64: 1403-18.

Heneka MT, O'Banion MK. Inflammatory processes in Alzheimer's disease. J Neuroimmunol. 2007;184:69-91.

Sano M. Tarenflurbil: Mechanisms and myths. Arch Neurol. 2010;67(6):750-2.

Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol. 2007; 8:101-12.

Muntimadugu E, Dhommati R, Jain A, Challa VG, Shaheen M, Khan W. Intranasal delivery of nanoparticle encapsulated tarenflurbil: A potential brain targeting strategy for Alzheimer's disease. Eur J Pharm Sci. 2016;92:224-34.

Zheng D, Shuai X, Li Y, Zhou P, Gong T, Sun X, et al. Novel flurbiprofen derivatives with improved brain delivery: synthesis, in vitro and in vivo evaluations. Drug Deliv. 2016;23(7):2183-92.

Brinton RD. Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends Pharmacol Sci. 2009;30(4):212-22.

Li Y, Liu L, Barger SW, Mrak RE, Griffin WST. Vitamin E Suppression of Microglial Activation Is Neuroprotective. J Neurosci Res. 2001;66(2):163-70.

Sutherland BA, Rahman RM, Appleton I. Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. J Nutr Biochem. 2006;17(5):291-306.

Sattayasai J, Chaonapan P, Arkaravichie T, Soi-ampornkul R, Junnu S, Charoensilp P, et al. Protective effects of mangosteen extract on H2O2-induced cytotoxicity in SK-N-SH cells and scopolamine-induced memory impairment in mice. PLoS One. 2013;8:e85053.

Singsai K, Akaravichien T, Kukongviriyapan V, Sattayasai J. Protective effects of Streblus asper leaf extract on H2O2-induced ROS in SK-N-SH Cells and MPTP-induced Parkinson’s disease-like symptoms in C57BL/6 mouse.

Evid Based Complement Alternat Med. 2015; 2015:970354.

Kotakadi VS, Jin Y, Hofseth AB, Ying L, Cui X, Volate S, et al. Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. Carcinogenesis. 2008; 29(9):1799-1806.

Zhang HF, Huang LB, Zhong YB, Zhou QH, Wang HL, Zheng GQ, et al. An overview of systematic reviews of Ginkgo biloba extracts for mild cognitive impairment and dementia. Front Aging Neurosci. 2016;8:276.

Yuan Q, Wang CW, Shi J, Lin ZX. Effects of Ginkgo biloba on dementia: An overview of systematic reviews. J Ethnopharmacol. 2017;195:1-9.

Fu Y, Zhou H, Wang M, Cen J, Wei Q. Immune regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana L. against collagen-induced arthritis. J Agric Food Chem. 2014;62(18):4127-34.

Sripanidkulchai B, Junlatat J, Wara-aswapati N, Hormdee D. Anti-inflammatory effect of Streblus asper leaf extract in rats and its modulation on inflammation-associated genes expression in RAW264.7 macrophage cells. J Ethnopharmacol. 2009;124:566-70.

Wannasin R, Sattayasai J, Puapairoj P, Arkaravichien T. Effects of Streblus asper leaves aqueous extract on learning and memory in male rats. Proceedings of the 4th Sino-Thai International Conference 2010; July 11-13; Khon Kaen, Thailand. 2010. p. 192–6.